Research activities

Biomedical research is the mission of Fondazione Pisana per la Scienza and selected scientific goals are pursued at the Foundation thanks to its scientific staff and resources.

FPS is open to collaboration within Pisan, national and international programs in which the biotechnological capabilities of the FPS laboratories are utilized to investigate key biomedical questions. Currently the FPS research program comprises three areas, oncology, neuroscience and cardiovascular system. A brief introduction to the research activities and the publications list, can be found by clicking the links below.



Cancer is a disease of great complexity of which we still have much to learn. This creates important opportunities ...


In the last decades, enormous effort was put into understanding how human brain is organized and functions. Such ...
Cardiovascular system

Cardiovascular system

According to the WHO, the burden of cardiovascular disorders is enormous, currently accounting for ~30% of deaths ...



Germline investigation in male breast cancer of DNA repair genes by next-generation sequencing. Scarpitta R, Zanna I, Aretini P, Gambino G, Scatena C, Mei B, Ghilli M, Rossetti E, Roncella M, Congregati C, Bonci F, Naccarato AG, Palli D, Caligo MA. Breast Cancer Res Treat. 2019 Dec;178(3): 557-564.

Brain-targeted enzyme-loaded nanoparticles: A breach through the blood-brain barrier for enzyme replacement therapy in Krabbe disease. Del Grosso A, Galliani M, Angella L, Santi M, Tonazzini I, Parlanti G, Signore G, Cecchini M. Science Advances, Volume 5, Issue 11, 20 November 2019.

HGF/MET pathway aberrations as diagnostic, prognostic, and predictive biomarkers in human cancers. Moosavi F, Giovannetti E, Saso L, Firuzi O. Crit Rev Clin Lab Sci. 2019 Dec;56(8):533-566.

Resistance mechanisms to osimertinib in EGFR-mutated non-small cell lung cancer. Leonetti A, Sharma S, Minari R, Perego P, Giovannetti E, Tiseo M. Br J Cancer. 2019 Oct;121(9):725-737.

Fast-diffusing p75NTR monomers support apoptosis and growth cone collapse by neurotrophin ligands. Marchetti L, Bonsignore F, Gobbo F, Amodeo R, Calvello M, Jacob A, Signore G, Schirripa Spagnolo C, Porciani D, Mainardi M, Beltram F, Luin S, Cattaneo A. Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21563-21572.

PTEN Alterations as a Potential Mechanism for Tumor Cell Escape from PD-1/PD-L1 Inhibition. Cretella D, Digiacomo G, Giovannetti E, Cavazzoni A. Cancers (Basel). 2019 Sep 6;11(9).

Mouse mammary tumor virus (MMTV) – like exogenous sequences are associated with sporadic but not hereditary human breast carcinoma. Naccarato AG, Lessi F, Zavaglia K, Scatena C, Al Hamad MA, Aretini P, Menicagli M, Roncella M, Ghilli M, Caligo MA, Mazzanti CM, Bevilacqua G. Aging (Albany NY). 2019 Sep 13;11(17):7236-7241.

Molecular basis and rationale for combining immune checkpoint inhibitors with chemotherapy in non-small cell lung cancer. Leonetti A, Wever B, Mazzaschi G, Assaraf YG, Rolfo C, Quaini F, Tiseo M, Giovannetti E. Drug Resist Updat. 2019 Sep;46:100644.

Dabrafenib and Trametinib prolong coagulation through the inhibition of tissue factor in BRAFv600e mutated melanoma cells in vitro. Scatena C, Franceschi S, Franzini M, Sanguinetti C, Romiti N, Caponi L, Mandalà M, Mazzanti CM, Naccarato AG. Cancer Cell Int. 2019 Aug 28;19:223. doi: 10.1186/s12935-019-0938-3.

Remarkable Effect of [Li(G4)]TFSI Solvate Ionic Liquid (SIL) on the Regio- and Stereoselective Ring Opening of α-Gluco Carbasugar 1,2-Epoxides. Di Pietro S, Bordoni V, Mezzetta A, Chiappe C, Signore G, Guazzelli L, Di Bussolo V. Molecules. 2019 Aug 14;24(16).

Unravelling the Diagnostic Dilemma: A MicroRNA Panel of Circulating MiR-16 and MiR-877 as A Diagnostic Classifier for Distal Bile Duct Tumors. Meijer LL, Puik JR, Le Large TYS, Heger M, Dijk F, Funel N, Wurdinger T, Garajová I, van Grieken NCT, van de Wiel MA, Giovannetti E, Kazemier G. Cancers (Basel). 2019 Aug 15;11(8). pii: E1181.

Can circulating tumor and exosomal nucleic acids act as biomarkers for pancreatic ductal adenocarcinoma? Liu DSK, Mato Prado M, Giovannetti E, Jiao LR, Krell J, Frampton AE. Expert Rev Mol Diagn. 2019 Jul;19(7):553-558.

Ultra-high resolution MALDI-FTICR-MSI analysis of intact proteins in mouse and human pancreas tissue. Piga I, Heijs B, Nicolardi S, Giusti L , Marselli L, Marchetti P, Mazzoni MR, Lucacchini, A., McDonnell, L.A. International Journal of Mass Spectrometry, Volume 437, March 2019, Pages 10-16.

Quantitative Microproteomics Based Characterization of the Central and Peripheral Nervous System of a Mouse Model of Krabbe Disease. Pellegrini D, Del Grosso A, Angella L, Giordano N, Dilillo M, Tonazzini I, Caleo M, Cecchini M, McDonnell LA. Mol Cell Proteomics. 2019 Jun;18(6):1227-1241.

Poly(Lactide‐Co‐Glycolide) Nanoparticles Co‐Loaded with Chlorophyllin and Quantum Dots as Photodynamic Therapy Agents. Galliani M, Signore G.  ChemPlusChem. Volume84, Issue11 November 2019, Pages 1653-1658.

Whole exome sequencing in familial isolated primary hyperparathyroidism. Cetani F, Pardi E, Aretini P, Saponaro F, Borsari S, Mazoni L, Apicella M, Civita P, La Ferla M, Caligo MA, Lessi F, Mazzanti CM, Torregrossa L, Oppo A, Marcocci C. J Endocrinol Invest. 2019 Sep 5.

The dichotomous role of the glycolytic metabolism pathway in cancer metastasis: Interplay with the complex tumor microenvironment and novel therapeutic strategies. El Hassouni B, Granchi C, Vallés-Martí A, Supadmanaba IGP, Bononi G, Tuccinardi T, Funel N, Jimenez CR, Peters GJ, Giovannetti E, Minutolo F. Semin Cancer Biol. 2019 Aug 21. pii: S1044-579X(19)30180-4.

ANKRD44 Gene Silencing: A Putative Role in Trastuzumab Resistance in Her2-Like Breast Cancer. La Ferla M, Lessi F, Aretini P, Pellegrini D, Franceschi S, Tantillo E, Menicagli M, Marchetti I, Scopelliti C, Civita P, De Angelis C, Diodati L, Bertolini I, Roncella M, McDonnell LA, Hochman J, Del Re M, Scatena C, Naccarato AG, Fontana A, Mazzanti CM. Front Oncol. 2019 Jun 26;9:547.

Biological Evaluation of the Antiproliferative and Anti-migratory Activity of a Series of 3-(6-Phenylimidazo[2,1-b][1,3,4]thiadiazol-2-yl)-1H-indole Derivatives Against Pancreatic Cancer Cells. Li Petri G, Cascioferro S, El Hassouni B, Carbone D, Parrino B, Cirrincione G, Peters GJ, Diana P, Giovannetti E. Anticancer Res. 2019 Jul;39(7):3615-3620.

Uridine Cytidine Kinase 2 as a Potential Biomarker for Treatment with RX-3117 in Pancreatic Cancer. El Hassouni B, Infante J, Mantini G, Ricci C, Funel N, Giovannetti E, Peters GJ.. Anticancer Res. 2019 Jul;39(7):3609-3614

A Brief Guide to Performing Pharmacological Studies In Vitro: Reflections from the EORTC-PAMM Course “Preclinical and Early-phase Clinical Pharmacology. Capula M, Corno C, El Hassouni B, Li Petri G, Aranđelović S; EORTC PAMM Group. Anticancer Res. 2019 Jul;39(7):3413-3418.

To Combine or Not Combine: Drug Interactions and Tools for Their Analysis. Reflections from the EORTC-PAMM Course on Preclinical and Early-phase. Clinical Pharmacology El Hassouni B, Mantini G, Li Petri G, Capula M, Boyd L, Weinstein HNW, Vallés-Marti A, Kouwenhoven MCM, Giovannetti E, Westerman BA, Peters GJ; EORTC PAMM Group. Anticancer Res. 2019 Jul;39(7):3303-3309.

Laser Capture Microdissection and RNA-Seq Analysis: High Sensitivity Approaches to Explain Histopathological Heterogeneity in Human Glioblastoma FFPE Archived Tissues. Civita P, Franceschi S, Aretini P, Ortenzi V, Menicagli M, Lessi F, Pasqualetti F, Naccarato AG, Mazzanti CM.. Front Oncol. 2019 Jun  7;9:482.

Rescuing cones and daylight vision in retinitis pigmentosa mice. Guadagni V, Biagioni M, Novelli E, Aretini P, Mazzanti CM, Strettoi E. FASEB J. 2019 Jun 14:fj201900414R.

Molecular profiling of microinvasive breast cancer microenvironment progression. Lessi F, Scatena C, Aretini P, Menicagli M, Franceschi S, Naccarato AG, Mazzanti CM. J Transl Med. 2019 Jun 3;17(1):187.

Pharmacogenetics of treatments for pancreatic cancer. El Hassouni B, Li Petri G, Liu DSK, Cascioferro S, Parrino B, Hassan W, Diana P, Ali A, Frampton AE, Giovannetti E.  Expert Opin Drug Metab Toxicol. 2019 Jun;15(6):437-447.

Decrease in phospho-PRAS40 plays a role in the synergy between erlotinib and crizotinib in an EGFR and cMET wild-type squamous non-small cell lung cancer cell line. Van Der Steen N, Leonetti A, Keller K, Dekker H, Funel N, Lardon F, Ruijtenbeek R, Tiseo M, Rolfo C, Pauwels P, Peters GJ, Giovannetti E. Biochem Pharmacol. 2019 Aug;166:128-138.

Role of c-MET Inhibitors in Overcoming Drug Resistance in Spheroid Models of Primary Human Pancreatic Cancer and Stellate Cells. Firuzi O, Che PP, El Hassouni B, Buijs M, Coppola S, Löhr M, Funel N, Heuchel R, Carnevale I, Schmidt T, Mantini G, Avan A, Saso L, Peters GJ, Giovannetti E. Cancers (Basel). 2019 May 8;11(5). pii: E638.

Nanocarriers for Protein Delivery to the Cytosol: Assessing the Endosomal Escape of Poly(Lactide-co-Glycolide)-Poly(Ethylene Imine) Nanoparticles. Galliani M, Tremolanti C, Signore G. Nanomaterials (Basel). 2019 Apr 23;9(4). pii: E652.

MICAL2 is expressed in cancer associated neo-angiogenic capillary endothelia and it is required for endothelial cell viability, motility and VEGF response. Barravecchia I, Mariotti S, Pucci A, Scebba F, De Cesari C, Bicciato S, Tagliafico E, Tenedini E, Vindigni C, Cecchini M, Berti G, Vitiello M, Poliseno L, Mazzanti CM, Angeloni D. Biochim Biophys Acta Mol Basis Dis. 2019 Apr 18. pii: S0925-4439(19)30119-X.

Monoallelic expression in melanoma. Silcock L, Almabrazi H, Mokrab Y, Jithesh P, Al-Hashmi M, James N, Mathew R, Mattei V, Bedognetti D, Lessi F, Temanni R, Seliger B, Al-Ali R, Marincola FM, Wang E, Tomei S. J Transl Med. 2019 Apr 5;17(1):112.

Overexpression of the cohesin-core subunit SMC1A contributes to colorectal cancer development. Sarogni P, Palumbo O, Servadio A, Astigiano S, D’Alessio B, Gatti V, Cukrov D, Baldari S, Pallotta MM, Aretini P, Dell’Orletta F, Soddu S, Carella M, Toietta G, Barbieri O, Fontanini G, Musio A. J Exp Clin Cancer Res. 2019 Mar 1;38(1):108.

2,6-Disubstituted imidazo[2,1-b][1,3,4]thiadiazole derivatives as potent staphylococcal biofilm inhibitors. Cascioferro S, Parrino B, Petri GL, Cusimano MG, Schillaci D, Di Sarno V, Musella S, Giovannetti E, Cirrincione G, Diana P. Eur J Med Chem. 2019 Apr 1;167:200-210.

Molecular characterization of low grade and high grade bladder cancer. Apollo A, Ortenzi V, Scatena C, Zavaglia K, Aretini P, Lessi F, Franceschi S, Tomei S, Sepich CA, Viacava P, Mazzanti CM, Naccarato AG.. PLoS One. 2019 Jan 16;14(1):e0210635.

Integrative Clustering in Mass Spectrometry Imaging for Enhanced Patient Stratification. Balluff B, Buck A, Martin-Lorenzo M, Dewez F, Langer R, McDonnell LA, Walch A, Heeren RMA. Proteomics Clin Appl. 2019 Jan;13(1):e1800137.

MicroRNAs as a drug resistance mechanism to targeted therapies in EGFR-mutated NSCLC: Current implications and future directions. Leonetti A, Assaraf YG, Veltsista PD, El Hassouni B, Tiseo M, Giovannetti E.  Drug Resist Updat. 2019 Jan;42:1-11.

Ultraviolet Photodissociation of ESI- and MALDI-Generated Protein Ions on a Q-Exactive Mass Spectrometer. Dilillo M, de Graaf EL, Yadav A, Belov ME, McDonnell LA.  J Proteome Res. 2019 Jan 4;18(1):557-564.

Development of a yeast-based system to identify new hBRAFV600E functional interactors. Lubrano S, Comelli L, Piccirilli C, Marranci A, Dapporto F, Tantillo E, Gemignani F, Gutkind JS, Salvetti A, Chiorino G, Cozza G, Chiariello M, Galli A, Poliseno L, Cervelli T. Oncogene. 2019 Feb;38(8):1355-1366.

The inherent molecular stigma in normal breast tissue of BRCA1/2 gene mutation carriers: TC1 and SYNGR2 genes involvement in neoplastic transformation. Mazzanti CM, Franceschi S, Scatena C, Menicagli M, Aretini P, Civita P, Scopelliti C, Tomei S, Tancredi M, Naccarato AG, Caligo MA, Lessi F. The inherent molecular stigma in normal breast tissue of BRCA1/2 gene mutation carriers: TC1 and SYNGR2 genes involvement in neoplastic transformation. January 17, 2019. Journal of Translational Sciences.


Assessing the potential of sputtered gold nanolayers in mass spectrometry imaging for metabolomics applications. Ràfols, P., Vilalta, D., Torres, S., Calavia, R., Heijs, B., McDonnell, L.A., Brezmes, J., del Castillo, E., Yanes, O., Ramìrez, N., Correig, X. (2018) PLoS One. 2018 Dec 12;13(12):e0208908.

MicroRNAs distribution in different phenotypes of Aortic Stenosis. Fabiani, I., Pugliese, N.R., Calogero, E., Conte, L., Mazzanti, M.C., Scatena, C., Scopelliti, C., Tantillo, E., Passiatore, M., Angelillis, M., Naccarato, G.A., Di Stefano, R., Petronio, A.S., Di Bello, V. (2018) ci Rep. 2018 Jul 2;8(1):9953.

Mitochondrial enzyme GLUD2 plays a critical role in glioblastoma progression. Franceschi, S., Corsinovi, D., Lessi, F., Tantillo, E., Aretini, P., Menicagli, M., Scopelliti, C., Civita, P., Pasqualetti, F., Naccarato, A.G., Ori, M., Mazzanti, C.M. EBioMedicine. 2018 Nov;37:56-67.

Doxycycline, an inhibitor of mitochondrial biogenesis, effectively reduces cancer stem cells (CSCs) in early breast cancer patients: A clinical pilot study. Scatena, C., Roncella, M., Di Paolo, A., Aretini, P., Menicagli, M., Fanelli, G., Marini, C., Mazzanti, C.M., Ghilli, M., Sotgia, F., Lisanti, M.P., Naccarato, A.G. Front Oncol. 2018 Oct 12;8:452.

Mass spectrometry imaging: How will it affect clinical research in the future? Dilillo, M., Heijs, B., McDonnell, L.A. Expert Rev Proteomics. 2018 Sep;15(9):709-716.

Round robin study of formalin-fixed paraffin-embedded tissues in mass spectrometry imaging. Buck, A., Heijs, B., Beine, B., Schepers, J., Cassese, A., Heeren, R.M.A., McDonnell, L.A., Henkel, C., Walch, A., Balluff, B. Anal Bioanal Chem. 2018 Sep;410(23):5969-5980.

Serotonin depletion causes valproate-responsive manic-like condition and increased hippocampal neuroplasticity that are reversed by stress. Maddaloni, G., Migliarini, S., Napolitano, F., Giorgi, A., Nazzi, S., Biasci, D., De Felice, A., Gritti, M., Cavaccini, A., Galbusera, A., Franceschi, S., Lessi, F., Ferla, M.L., Aretini, P., Mazzanti, C.M., Tonini, R., Gozzi, A., Usiello, A., Pasqualetti, M. Sci Rep. 2018 Aug 7;8(1):11847.

Next generation sequencing technologies for a successful diagnosis in a cold case of Leigh syndrome. Aretini, P., Mazzanti, C.M., La Ferla, M., Franceschi, S., Lessi, F., De Gregorio, V., Nesti, C., Valetto, A., Bertini, V., Toschi, B., Battini, R., Caligo, M.A. BMC Neurol. 2018 Jul 20;18(1):99.

Mouse mammary tumour virus-like env nucleotide and p14 signal peptide are present in feline mammary carcinomas, but not in neoplastic or dysplastic canine mammary lesions. Civita, P., Menicagli, M., Scopelliti, C., Lessi, F., Millanta, F., Borsacchi, S., Parisi, F., Freer, G., Pistello, M., Mazzanti, C.M., Poli, A. (2018) PLoS One. 2018 Jul 24;13(7):e0200839.

Characterization of Degraded Proteins in Paintings Using Bottom-Up Proteomic Approaches: New Strategies for Protein Digestion and Analysis of Data. Orsini, S., Yadav, A., Dilillo, M., McDonnell, L.A., Bonaduce, I. Anal Chem. 2018 Jun 5;90(11):6403-6408.

Bacterial toxins and targeted brain therapy: New insights from cytotoxic necrotizing factor 1 (CNF1). Tantillo, E., Colistra, A., Vannini, E., Cerri, C., Pancrazi, L., Baroncelli, L., Costa, M., Caleo, M. Int J Mol Sci. 2018 May 31;19(6).

Association of mouse mammary tumor virus with human breast cancer: Histology, immunohistochemistry and polymerase chain reaction analyses. Lawson, J.S., Mazzanti, C., Civita, P., Menicagli, M., Ngan, C.C., Whitaker, N.J., Hochman, J., Braitbard, O., Yosufi, B., Glenn, W.K. Front Oncol. 2018 May 7;8:141.

Cancer astrocytes have a more conserved molecular status in long recurrence free survival (RFS) IDH1 wild-type glioblastoma patients: New emerging cancer players. Franceschi, S., Lessi, F., Aretini, P., Ortenzi, V., Scatena, C., Menicagli, M., La Ferla, M., Civita, P., Zavaglia, K., Scopelliti, C., Apollo, A., Carbone, F.G., Vannozzi, R., Bevilacqua, G., Pasqualetti, F., Naccarato, A.G., Mazzanti, C.M. Oncotarget. 2018 May 8;9(35):24014-24027.

Levels of miR-126 and miR-218 are elevated in ductal carcinoma in situ (DCIS) and inhibit malignant potential of DCIS derived cells. Volinia, S., Bertagnolo, V., Grassilli, S., Brugnoli, F., Manfrini, M., Galasso, M., Scatena, C., Mazzanti, C.M., Lessi, F., Naccarato, G., Caligo, A., Bianchini, E., Piubello, Q., Orvieto, E., Rugge, M., Natali, C., Reale, D., Vecchione, A., Warner, S., Croce, C.M., Capitani, S. Oncotarget. 2018 May 4;9(34):23543-23553.

Role of circulating endothelial progenitor cells in the reparative mechanisms of stable ischemic myocardium. Morrone, D., Felice, F., Scatena, C., De Martino, A., Picoi, M.L.E., Mancini, N., Blasi, S., Menicagli, M., Di Stefano, R., Bortolotti, U., Naccarato, A.G., Balbarini, A. Int J Cardiol. 2018 Apr 15;257:243-246.

Association of Glutathione S-Transferase P-1 (GSTP-1) rs1695 polymorphism with overall survival in glioblastoma patients treated with combined radio-chemotherapy. Pasqualetti, F., Gonnelli, A., Cantarella, M., Delishaj, D., Molinari, A., Ortenzi, V., Carbone, F., Montrone, S., Ursino, S., Franceschi, S., Morganti, R., Orlandi, P., Di Desidero, T., Mazzanti, C.M., Zavaglia, K., Naccarato, A.G., Bocci, G., Paiar, F. Invest New Drugs. 2018 Apr;36(2):340-345.

Interactive Visual Exploration of 3D Mass Spectrometry Imaging Data Using Hierarchical Stochastic Neighbor Embedding Reveals Spatiomolecular Structures at Full Data Resolution. Abdelmoula, W.M., Pezzotti, N., Holt, T., Dijkstra, J., Vilanova, A., McDonnell, L.A., Lelieveldt, B.P.F. J Proteome Res. 2018 Mar 2;17(3):1054-1064.

Mass spectrometry imaging of metabolites. Balluff, B., McDonnell, L.A. Methods Mol Biol. 2018;1730:345-357.


Role of Glutathione S-Transferase P polymorphism rs51695 in glioblastoma patients treated with combined radio-chemotherapy F Pasqualetti, A Gonnelli, M Cantarella, D Durim, A Molinari, V Ortenzi, F Carbone, S Montrone, S Ursino, S Franceschi, R Morganti, P Orlandi, T Di Desiderio, CM Mazzanti, G Bocci, K Zavaglia, AG Naccarato, F Paiar, MD: Invest New Drugs. 2017 Sep 30.

SGLT2/ SGLT1 expression in renal tissue of patients with type 2 diabetes. A Solini, C Rossi, CM Mazzanti, A Proietti, H Koepsell, E Ferrannini. Diabetes Obes Metab. 2017 Sep;19(9):1289-1294

Role of circulating endothelial progenitor cells in the reparative mechanisms of stable ischemic myocardium. Morrone D, Felice F, Scatena C, De Martino A, Picoi MLE, Mancini N, Blasi S, Menicagli M, Di Stefano R, Bortolotti U, Naccarato AG, Balbarini A. Int J Cardiol. 2017 Sep 14. pii: S0167-5273(16)32271-9.

Whole-exome analysis of a Li-Fraumeni family trio with a novel TP53 PRD mutation and anticipation profile.Franceschi S, Spugnesi L, Aretini P, Lessi F, Scarpitta R, Galli A, Congregati C, Caligo MA, Mazzanti CM. Carcinogenesis. 2017 Sep 1;38(9):938-943.

Sodium-glucose co transporter (SGLT)2 and SGLT1 renal expression in patients with type 2 diabetes. Solini A, Rossi C, Mazzanti CM, Proietti A, Koepsell H, Ferrannini E. Diabetes Obes Metab. 2017 Sep;19(9):1289-1294.

CXCL12α/SDF-1 from perisynaptic Schwann cells promotes regeneration of injured motor axon terminals. Negro S, Lessi F, Duregotti E, Aretini P, La Ferla M, Franceschi S, Menicagli M, Bergamin E, Radice E, Thelen M, Megighian A, Pirazzini M, Mazzanti CM, Rigoni M, Montecucco C. EMBO Mol Med. 2017 Aug;9(8):1000-1010.

Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells. Lai M, Realini N, La Ferla M, Passalacqua I, Matteoli G, Ganesan A, Pistello M, Mazzanti CM, Piomelli D. Sci Rep. 2017 Aug 7;7(1):7411.

Mass Spectrometry Imaging, Laser Capture Microdissection, and LC-MS/MS of the Same Tissue Section. Dilillo M, Pellegrini D, Ait-Belkacem R, de Graaf EL, Caleo M, McDonnell LA. J Proteome Res. 2017 Aug 4;16(8):2993-3001.

Design and Performance of a Novel Interface for Combined Matrix-Assisted Laser Desorption Ionization at Elevated Pressure and Electrospray Ionization with Orbitrap Mass Spectrometry. Belov ME, Ellis SR, Dilillo M, Paine MRL, Danielson WF, Anderson GA, de Graaf EL, Eijkel GB, Heeren RMA, McDonnell LA. Anal Chem. 2017 Jul 18;89(14):7493-7501.

Polymorphisms and mutations in GSTP1, RAD51, XRCC1 and XRCC3 genes in breast cancer patients. Al Zoubi MS, Zavaglia K, Mazanti C, Al Hamad M, Al Batayneh K, Aljabali AAA, Bevilacqua G.Int J Biol Markers. 2017 Jul 24;32(3):e337-e343.

Whole-exome analysis in osteosarcoma to identify a personalized therapy. Chiappetta C, Mancini M, Lessi F, Aretini P, De Gregorio V, Puggioni C, Carletti R, Petrozza V, Civita P, Franceschi S, Naccarato AG, Rocca CD, Mazzanti CM, Di Cristofano C. Oncotarget. 2017 Jul 5;8(46):80416-80428.

Design and Performance of a Novel Interface for Combined Matrix-Assisted Laser Desorption Ionization at Elevated Pressure and Electrospray Ionization with Orbitrap Mass Spectrometry. Belov ME, Ellis SR, Dilillo M, Paine MRL, Danielson WF, Anderson GA, de Graaf EL, Eijkel GB, Heeren RMA, McDonnell LA. Anal Chem. 2017 Jul 18;89(14):7493-7501.

Mass spectrometry imaging shows major derangements in neurogranin and in purine metabolism in the triple-knockout 3×Tg Alzheimer mouse model. Esteve C, Jones EA, Kell DB, Boutin H, McDonnell LA. Biochim Biophys Acta. 2017 Jul;1865(7):747-754.

Loss of c-KIT expression in thyroid cancer cells. S Franceschi, F Lessi, F Panebianco, E Tantillo, M La Ferla, M Menicagli, P Aretini, A Apollo, AG Naccarato, I Marchetti, CM Mazzanti. PLoS One. 2017 Mar 16;12(3)

Preface. Drake RR, McDonnell LA. Adv Cancer Res. 2017;134:xiii-xiv.

Mass Spectrometry Imaging in Cancer Research: Future Perspectives. McDonnell LA, Angel PM, Lou S, Drake RR. Adv Cancer Res. 2017;134:283-290.

Ultra-High Mass Resolution MALDI Imaging Mass Spectrometry of Proteins and Metabolites in a Mouse Model of Glioblastoma. Dilillo M, Ait-Belkacem R, Esteve C, Pellegrini D, Nicolardi S, Costa M, Vannini E, Graaf EL, Caleo M, McDonnell LA. Sci Rep. 2017 Apr 4;7(1):603.

Mouse mammary tumor-like virus (MMTV) is present in human breast tissue before development of virally associated breast cancer. Nartey T, Mazzanti CM, Melana S, Glenn WK, Bevilacqua G, Holland JF, Whitaker NJ, Lawson JS, Pogo BGT. Infect Agent Cancer. 2017 Mar 15;12:16.

Human Plasma N-glycosylation as Analyzed by Matrix-Assisted Laser Desorption/Ionization-Fourier Transform Ion Cyclotron Resonance-MS Associates with Markers of Inflammation and Metabolic Health. Reiding KR, Ruhaak LR, Uh HW, El Bouhaddani S, van den Akker EB, Plomp R, McDonnell LA, Houwing-Duistermaat JJ, Slagboom PE, Beekman M, Wuhrer M. Mol Cell Proteomics. 2017 Feb;16(2):228-242.

Prognostic Metabolite Biomarkers for Soft Tissue Sarcomas Discovered by Mass Spectrometry Imaging. Lou S, Balluff B, Cleven AH, Bovée JV, McDonnell LA. J Am Soc Mass Spectrom. 2017 Feb;28(2):376-383.

Hybrid Imaging Labels: Providing the Link Between Mass Spectrometry-Based Molecular Pathology and Theranostics. Buckle T, van der Wal S, van Malderen SJ, Müller L, Kuil J, van Unen V, Peters RJ, van Bemmel ME, McDonnell LA, Velders AH, Koning F, Vanhaeke F, van Leeuwen FW. Theranostics. 2017 Jan 12;7(3):624-633.


de Graaf EL, Pellegrini D, McDonnell LA. Set of Novel Automated Quantitative Microproteomics Protocols for Small Sample Amounts and Its Application to Kidney Tissue Substructures. J Proteome Res. 2016 Dec 2;15(12):4722-4730.

Ait-Belkacem R, Dilillo M, Pellegrini D, Yadav A, de Graaf EL, McDonnell LA. In-Source Decay and Pseudo-MS(3) of Peptide and Protein Ions Using Liquid AP-MALDI. J Am Soc Mass Spectrom. 2016 Dec;27(12):2075-2079.

Fabiani I, Scatena C, Mazzanti CM, Conte L, Pugliese NR, Franceschi S, Lessi F, Menicagli M, De Martino A, Pratali S, Bortolotti U, Naccarato AG, La Carrubba S, Di Bello V. Micro-RNA-21 (biomarker) and global longitudinal strain (functional marker) in detection of myocardial fibrotic burden in severe aortic valve stenosis: a pilot study. J Transl Med. 2016 Aug 27;14(1):248.

Ly A, Buck A, Balluff B, Sun N, Gorzolka K, Feuchtinger A, Janssen KP, Kuppen PJ, van de Velde CJ, Weirich G, Erlmeier F, Langer R, Aubele M, Zitzelsberger H, McDonnell L, Aichler M, Walch A. High-mass-resolution MALDI mass spectrometry imaging of metabolites from formalin-fixed paraffin-embedded tissue. Nat Protoc. 2016 Aug;11(8):1428-43.

Heijs B, Holst S, Briaire-de Bruijn IH, van Pelt GW, de Ru AH, van Veelen PA, Drake RR, Mehta AS, Mesker WE, Tollenaar RA, Bovée JV, Wuhrer M, McDonnell LA. Multimodal Mass Spectrometry Imaging of N-Glycans and Proteins from the Same Tissue Section. Anal Chem. 2016 Aug 2;88(15):7745-53.

Spugnesi L, Gabriele M, Scarpitta R, Tancredi M, Maresca L, Gambino G, Collavoli A, Aretini P, Bertolini I, Salvadori B, Landucci E, Fontana A, Rossetti E, Roncella M, Naccarato GA, Caligo MA. Germline mutations in DNA repair genes may predict neoadjuvant therapy response in triple negative breast patients. Genes Chromosomes Cancer. 2016 Dec;55(12):915-924.

Schmidlin T, Garrigues L, Lane CS, Mulder TC, van Doorn S, Post H, de Graaf EL, Lemeer S, Heck AJ, Altelaar AF. Assessment of SRM, MRM(3) , and DIA for the targeted analysis of phosphorylation dynamics in non-small cell lung cancer. Proteomics. 2016 Aug;16(15-16):2193-205.

Cassese A, Ellis SR, Ogrinc Potočnik N, Burgermeister E, Ebert M, Walch A, van den Maagdenberg AM, McDonnell LA, Heeren RM, Balluff B. Spatial Autocorrelation in Mass Spectrometry Imaging. Anal Chem. 2016 Jun 7;88(11):5871-8.

Lou S, Balluff B, de Graaff MA, Cleven AH, Briaire-de Bruijn I, Bovée JV, McDonnell LA. High-grade sarcoma diagnosis and prognosis: Biomarker discovery by mass spectrometry imaging. Proteomics. 2016 Jun;16(11-12):1802-13.

Holst S, Heijs B, de Haan N, van Zeijl RJ, Briaire-de Bruijn IH, van Pelt GW, Mehta AS, Angel PM, Mesker WE, Tollenaar RA, Drake RR, Bovée JV, McDonnell LA, Wuhrer M. Linkage-Specific in Situ Sialic Acid Derivatization for N-Glycan Mass Spectrometry Imaging of Formalin-Fixed Paraffin-Embedded Tissues. Anal Chem. 2016 Jun 7;88(11):5904-13.

Mulder IA, Esteve C, Wermer MJ, Hoehn M, Tolner EA, van den Maagdenberg AM, McDonnell LA. Funnel-freezing versus heat-stabilization for the visualization of metabolites by mass spectrometry imaging in a mouse stroke model. Proteomics. 2016 Jun;16(11-12):1652-9.

Franceschi S, Lessi F, Aretini P, Mazzanti CM, Menicagli M, La Ferla M, De Gregorio V, Caramella D, Naccarato AG, Bevilacqua G, Bonadio AG, Pasqualetti F. Molecular portrait of a rare case of metastatic glioblastoma: somatic and germline mutations using whole-exome sequencing. Neuro Oncol. 2016 Feb;18(2):298-300.

Lai M, Pifferi M, Bush A, Piras M, Michelucci A, Di Cicco M, del Grosso A, Quaranta P, Cursi C, Tantillo E, Franceschi S, Mazzanti MC, Simi P, Saggese G, Boner A, Pistello M. Gene editing of DNAH11 restores normal cilia motility in primary ciliary dyskinesia. J Med Genet. 2016 Apr;53(4):242-9.

Mariotti S, Barravecchia I, Vindigni C, Pucci A, Balsamo M, Libro R, Senchenko V, Dmitriev A, Jacchetti E, Cecchini M, Roviello F, Lai M, Broccoli V, Andreazzoli M, Mazzanti CM, Angeloni D. MICAL2 is a novel human cancer gene controlling mesenchymal to epithelial transition involved in cancer growth and invasion. Oncotarget. 2016 Jan 12;7(2):1808-25.

Franceschi S, Tomei S, Mazzanti CM, Lessi F, Aretini P, La Ferla M, De Gregorio V, Pasqualetti F, Zavaglia K, Bevilacqua G, Naccarato AG. Association between RAD 51 rs1801320 and susceptibility to glioblastoma. J Neurooncol. 2016 Jan;126(2):265-70.