Attività di ricerca

La ricerca biomedica è la missione principale della Fondazione Pisana per la Scienza. Obiettivi scientifici selezionati vengono perseguiti in Fondazione grazie al suo personale e alle sue risorse scientifiche.

La FPS è aperta a collaborazioni all’interno di programmi della comunità scientifica pisana, nazionale ed internazionale, in cui vengono utilizzate le capacità dei laboratori biotecnologici della FPS per investigare le principali questioni di ordine biomedico. Attualmente il programma di ricerca della FPS si compone di tre aree, oncologia, neuroscienze e sistema cardiovascolare. Una breve presentazione delle attività di ricerca e l’elenco delle pubblicazioni, si possono consultare cliccando i collegamenti riportati di seguito.

Oncologia

Oncologia

Il cancro è una malattia di grande complessità e continua a rappresentare un campo di studio in evoluzione, con ...
Neuroscienze

Neuroscienze

Negli ultimi decenni uno sforzo considerevole è stato rivolto alla comprensione del cervello umano, alla sua ...
Sistema Cardiovascolare

Sistema Cardiovascolare

Secondo l'OMS, l’impatto delle malattie cardiovascolari è enorme essendo responsabili di circa il 30% dei ...

FPS Grant

2022

Circulating tumor cells as a non-invasive glioblastoma approach to study recurrence events and develop a challenging diagnostic tool
Research Team: Francesca Lessi, Chiara Maria Mazzanti, Sara Franceschi, Mariangela Morelli, Paolo Aretini, Michele Menicagli, Gianmarco Ferri

2020

Characterization of α-synuclein isoforms SUMOylation profile and its impact on α-synuclein homeostasis and pathophysiology in Parkinson’s disease
Research team:
Marco Feligioni, Kambiz Hassanzadeh

Precision Exosome Analysis for Early Diagnosis of Pancreatic Cancer
Team di ricerca: Liam A. McDonnell, Elisa Giovannetti, Asia Botto

Hybrid nanosensors for in vivo detection of circulating tumor-specific biomarkers
Research team: Giovanni Signore, Gianmarco Ferri, Pasquale Mastella, Elisa Ottalagana.

2018

Human disease modeling of GATA2-related Myelodysplastic Syndromes and Acute Myeloid Leukemia
Research team:
Alessandra Giorgetti, Paolo Aretini, Francesca Lessi, Chiara Mazzanti, Damia Romero-Moya

Dissection of Aβ oligomer synaptotoxic signaling in human neocortical neurons
Research team: Maria Teresa Dell’Anno, Francesco Olimpico

Optical Metabolic Imaging (OMI) Of Glioblastoma Patient Derived Organoids To Assess Treatment Response And Disease Progression
Research team: Chiara Mazzanti, Mariangela Morelli, Sara Franceschi, Francesca Lessi, Paolo Aretini, Michele Menicagli, Gianmarco Ferri, Giovanni Signore

Pubblicazioni

2022

Parisi F, Lessi F, Menicagli M, Civita P, Liotti R, Millanta F, Freer G, Pistello M, Mazzanti CM, Poli A. Presence of a mouse mammary tumour virus-like in feline lymphomas: a preliminary study. Infect Agent Cancer. 2022 Jun 23;17(1):35. doi: 10.1186/s13027-022-00449-9. PMID: 35739602.

Lessi F, Franceschi S, Morelli M, Menicagli M, Pasqualetti F,  Santonocito O, Gambacciani C, Pieri F, Aquila F, Aretini P and Mazzanti CM. Single-cell molecular characterization to partition the human glioblastoma tumor microenvironment genetic background. Cells. 2022 Mar 26;11(7):1127. doi: 10.3390/cells11071127. PMID: 354066902022. IF:7,666

Degl’Innocenti E, Poloni TE, Medici V, Recupero L, Dell’amico C, Borello U, Mazzanti CM, Onorati M and Dell’Anno MT. Centrin 2: a novel marker of mature and neoplastic human astrocytes. Front. Cell. Neurosci.  2022 Apr 29;16:858347. doi: 10.3389/fncel.2022.858347. PMID: 35573835. IF: 6,147

Negro S, Lauria F, Stazi M, Tebaldi T, D’Este G, Pirazzini M, Megighian A, Lessi F, Mazzanti CM, Sales G, Romualdi C, Fillo S, Lista F, Sleigh JN, Tosolini AP, Schiavo G, Viero G, Rigoni M. Hydrogen peroxide induced by nerve injury promotes axon regeneration via connective tissue growth factor. Acta Neuropathol Commun. 2022 Dec 25;10(1):189. doi: 10.1186/s40478-022-01495-5. PMID: 36567321; PMCID: PMC9791753.

Giovannetti E. Editorial: Women in pharmacology of anti-cancer drugs: 2021. Front Pharmacol. 2022 Nov 30;13:1092204. doi: 10.3389/fphar.2022.1092204. PMID: 36532781; PMCID: PMC9748683.

Costantino L, Ferrari S, Santucci M, Salo-Ahen OMH, Carosati E, Franchini S, Lauriola A, Pozzi C, Trande M, Gozzi G, Saxena P, Cannazza G, Losi L, Cardinale D, Venturelli A, Quotadamo A, Linciano P, Tagliazucchi L, Moschella MG, Guerrini R, Pacifico S, Luciani R, Genovese F, Henrich S, Alboni S, Santarem N, da Silva Cordeiro A, Giovannetti E, Peters GJ, Pinton P, Rimessi A, Cruciani G, Stroud RM, Wade RC, Mangani S, Marverti G, D’Arca D, Ponterini G, Costi MP. Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth. Elife. 2022 Dec 7;11:e73862. doi: 10.7554/eLife.73862. PMID: 36475542; PMCID: PMC9831607.

Boyd LNC, Ali M, Leeflang MMG, Treglia G, de Vries R, Le Large TYS, Besselink MG, Giovannetti E, van Laarhoven HWM, Kazemier G. Diagnostic accuracy and added value of blood-based protein biomarkers for pancreatic cancer: A meta-analysis of aggregate and individual participant data. EClinicalMedicine. 2022 Nov 24;55:101747. doi: 10.1016/j.eclinm.2022.101747. PMID: 36457649; PMCID: PMC9706531.

Meneghetti N, Cerri C, Vannini E, Tantillo E, Tottene A, Pietrobon D, Caleo M, Mazzoni A. Synaptic alterations in visual cortex reshape contrast-dependent gamma oscillations and inhibition-excitation ratio in a genetic mouse model of migraine. J Headache Pain. 2022 Sep 29;23(1):125. doi:10.1186/s10194-022-01495-9. PMID: 36175826; PMCID: PMC9523950.

Morelli M, Lessi F, Barachini S, Liotti R, Montemurro N, Perrini P, Santonocito OS, Gambacciani C, Snuderl M, Pieri F, Aquila F, Farnesi A, Naccarato AG, Viacava P, Cardarelli F, Ferri G, Mulholland P, Ottaviani D, Paiar F, Liberti G, Pasqualetti F, Menicagli M, Aretini P, Signore G, Franceschi S, Mazzanti CM. Metabolic-imaging of human glioblastoma live tumors: A new precision-medicine approach to predict tumor treatment response early. Front Oncol. 2022 Sep 5;12:969812. doi: 10.3389/fonc.2022.969812. PMID: 36132155; PMCID: PMC9483168.

Capula M, Perán M, Xu G, Donati V, Yee D, Gregori A, Assaraf YG, Giovannetti E, Deng D. Role of drug catabolism, modulation of oncogenic signaling and tumor microenvironment in microbe-mediated pancreatic cancer chemoresistance. Drug Resist Updat. 2022 Sep;64:100864. doi: 10.1016/j.drup.2022.100864. Epub 2022 Sep 6. PMID: 36115181.

Comandatore A, Franczak M, Smolenski RT, Morelli L, Peters GJ, Giovannetti E. Lactate Dehydrogenase and its clinical significance in pancreatic and thoracic cancers. Semin Cancer Biol. 2022 Nov;86(Pt 2):93-100. doi: 10.1016/j.semcancer.2022.09.001. Epub 2022 Sep 9. PMID: 36096316.

Pasqualetti F, Rizzo M, Franceschi S, Lessi F, Paiar F, Buffa FM. New perspectives in liquid biopsy for glioma patients. Curr Opin Oncol. 2022 Nov 1;34(6):705-712. doi: 10.1097/CCO.0000000000000902. Epub 2022 Sep 12. PMID: 36093876.

Balsano R, Kruize Z, Lunardi M, Comandatore A, Barone M, Cavazzoni A, Re Cecconi AD, Morelli L, Wilmink H, Tiseo M, Garajovà I, van Zuylen L, Giovannetti E, Piccirillo R. Transforming Growth Factor-Beta Signaling in Cancer-Induced Cachexia: From Molecular Pathways to the Clinics. Cells. 2022 Aug 28;11(17):2671. doi: 10.3390/cells11172671. PMID: 36078078; PMCID: PMC9454487.

Puik JR, Swijnenburg RJ, Kazemier G, Giovannetti E. Novel Strategies to Address Critical Challenges in Pancreatic Cancer. Cancers (Basel). 2022 Aug 25;14(17):4115. doi: 10.3390/cancers14174115. PMID: 36077652; PMCID: PMC9454690.

Mapanao AK, Sarogni P, Santi M, Menicagli M, Gonnelli A, Zamborlin A, Ermini ML, Voliani V. Pro-apoptotic and size-reducing effects of protein corona-modulating nano-architectures enclosing platinum prodrug in in vivo oral carcinoma. Biomater Sci. 2022 Oct 25;10(21):6135-6145. doi: 10.1039/d2bm00994c. PMID: 36069269.

In ‘t Veld SGJG, Arkani M, Post E, Antunes-Ferreira M, D’Ambrosi S, Vessies DCL, Vermunt L, Vancura A, Muller M, Niemeijer AN, Tannous J, Meijer LL, Le Large TYS, Mantini G, Wondergem NE, Heinhuis KM, van Wilpe S, Smits AJ, Drees EEE, Roos E, Leurs CE, Tjon Kon Fat LA, van der Lelij EJ, Dwarshuis G, Kamphuis MJ, Visser LE, Harting R, Gregory A, Schweiger MW, Wedekind LE, Ramaker J, Zwaan K, Verschueren H, Bahce I, de Langen AJ, Smit EF, van den Heuvel MM, Hartemink KJ, Kuijpers MJE, Oude Egbrink MGA, Griffioen AW, Rossel R, Hiltermann TJN, Lee-Lewandrowski E, Lewandrowski KB, De Witt Hamer PC, Kouwenhoven M, Reijneveld JC, Leenders WPJ, Hoeben A, Verdonck-de Leeuw IM, Leemans CR, Baatenburg de Jong RJ, Terhaard CHJ, Takes RP, Langendijk JA, de Jager SC, Kraaijeveld AO, Pasterkamp G, Smits M, Schalken JA, Łapińska-Szumczyk S, Łojkowska A, Żaczek AJ, Lokhorst H, van de Donk NWCJ, Nijhof I, Prins HJ, Zijlstra JM, Idema S, Baayen JC, Teunissen CE, Killestein J, Besselink MG, Brammen L, Bachleitner-Hofmann T, Mateen F, Plukker JTM, Heger M, de Mast Q, Lisman T, Pegtel DM, Bogaard HJ, Jassem J, Supernat A, Mehra N, Gerritsen W, de Kroon CD, Lok CAR, Piek JMJ, Steeghs N, van Houdt WJ, Brakenhoff RH, Sonke GS, Verheul HM, Giovannetti E, Kazemier G, Sabrkhany S, Schuuring E, Sistermans EA, Wolthuis R, Meijers- Heijboer H, Dorsman J, Oudejans C, Ylstra B, Westerman BA, van den Broek D, Koppers-Lalic D, Wesseling P, Nilsson RJA, Vandertop WP, Noske DP, Tannous BA, Sol N, Best MG, Wurdinger T. Detection and localization of early- and late-stage cancers using platelet RNA. Cancer Cell. 2022 Sep 12;40(9):999-1009.e6. doi: 10.1016/j.ccell.2022.08.006. Epub 2022 Sep 1. PMID: 36055228.

Cappelletti P, Filareti M, Masuelli L, Bei R, Hassanzadeh K, Corbo M, Feligioni M. Syntaxin-1a and SNAP-25 expression level is increased in the blood samples of ischemic stroke patients. Sci Rep. 2022 Aug 25;12(1):14483. doi: 10.1038/s41598-022-18719-2. PMID: 36008522; PMCID: PMC9411545.

Garajová I, Cavazzoni A, Verze M, Minari R, Pedrazzi G, Balsano R, Gelsomino F, Valle RD, Digiacomo G, Giovannetti E, Leonardi F. It Takes Two to Tango: Potential Prognostic Impact of Circulating TGF-Beta and PD-L1 in Pancreatic Cancer. Life (Basel). 2022 Jun 26;12(7):960. doi: 10.3390/life12070960. PMID: 35888050; PMCID: PMC9323895.

Amerizadeh F, Rahmani F, Maftooh M, Nasiri SN, Hassanian SM, Giovannetti E, Moradi-Marjaneh R, Sabbaghzadeh R, Shahidsales S, Joudi-Mashhad M, Ghayour-Mobarhan M, Ferns GA, Khazaei M, Avan A. Inhibition of the Wnt/b-catenin pathway using PNU-74654 reduces tumor growth in in vitro and in vivo models of colorectal cancer. Tissue Cell. 2022 Aug;77:101853. doi: 10.1016/j.tice.2022.101853. Epub 2022 Jun 15. PMID: 35803035.

Gaeta R, Righi A, Gambarotti M, Aretini P, Lessi F, Mazzanti CM, Mancini I, Pinzani P, Belgio B, Sbaraglia M, Tos APD, Franchi A. Chondroblastoma-like osteosarcoma: a clinicopathological and molecular study of a rare osteosarcoma variant. Histopathology. 2022 Sep;81(3):389-401. doi: 10.1111/his.14721. Epub 2022 Jul 19. PMID: 35791778.

Kotmayer L, Romero-Moya D, Marin-Bejar O, Kozyra E, Català A, Bigas A, Wlodarski MW, Bödör C, Giorgetti A. GATA2 deficiency and MDS/AML: Experimental strategies for disease modelling and future therapeutic prospects. Br J Haematol. 2022 Nov;199(4):482-495. doi: 10.1111/bjh.18330. Epub 2022 Jun 26. PMID: 35753998; PMCID: PMC9796058.

Che PP, Mapanao AK, Gregori A, Ermini ML, Zamborlin A, Capula M, Ngadimin D, Slotman BJ, Voliani V, Sminia P, Giovannetti E. Biodegradable Ultrasmall-in-Nano Architectures Loaded with Cisplatin Prodrug in Combination with Ionizing Radiation Induces DNA Damage and Apoptosis in Pancreatic Ductal Adenocarcinoma. Cancers (Basel). 2022 Jun 20;14(12):3034. doi: 10.3390/cancers14123034. PMID: 35740699; PMCID: PMC9221262.

Tentori P, Signore G, Camposeo A, Carretta A, Ferri G, Pingue P, Luin S, Pozzi D, Gratton E, Beltram F, Caracciolo G, Cardarelli F. Fluorescence lifetime microscopy unveils the supramolecular organization of liposomal Doxorubicin. Nanoscale. 2022 Jun 30;14(25):8901-8905. doi: 10.1039/d2nr00311b. PMID: 35719059.

Franceschi S, Lessi F, Morelli M, Menicagli M, Pasqualetti F, Aretini P, Mazzanti CM. Sedoheptulose Kinase SHPK Expression in Glioblastoma: Emerging Role of the Nonoxidative Pentose Phosphate Pathway in Tumor Proliferation. Int J Mol Sci. 2022 May 26;23(11):5978. doi: 10.3390/ijms23115978. PMID: 35682658; PMCID: PMC9180619.

Doccini S, Marchese M, Morani F, Gammaldi N, Mero S, Pezzini F, Soliymani R, Santi M, Signore G, Ogi A, Rocchiccioli S, Kanninen KM, Simonati A, Lalowski MM, Santorelli FM. Lysosomal Proteomics Links Disturbances in Lipid Homeostasis and Sphingolipid Metabolism to CLN5 Disease. Cells. 2022 Jun 4;11(11):1840. doi: 10.3390/cells11111840. PMID: 35681535; PMCID: PMC9180748.

Parisi F, Freer G, Mazzanti CM, Pistello M, Poli A. Mouse Mammary Tumor Virus (MMTV) and MMTV-like Viruses: An In-depth Look at a Controversial Issue. Viruses. 2022 May 6;14(5):977. doi: 10.3390/v14050977. PMID: 35632719; PMCID: PMC9147501.

Maurici CE, Colenbier R, Wylleman B, Brancato L, van Zwol E, Van den Bossche J, Timmermans JP, Giovannetti E, Mori da Cunha MGMC, Bogers J. Hyperthermia Enhances Efficacy of Chemotherapeutic Agents in Pancreatic Cancer Cell Lines. Biomolecules. 2022 Apr 29;12(5):651. doi: 10.3390/biom12050651. PMID: 35625581; PMCID: PMC9138677.

De Santis MC, Gozzelino L, Margaria JP, Costamagna A, Ratto E, Gulluni F, Di Gregorio E, Mina E, Lorito N, Bacci M, Lattanzio R, Sala G, Cappello P, Novelli F, Giovannetti E, Vicentini C, Andreani S, Delfino P, Corbo V, Scarpa A, Porporato PE, Morandi A, Hirsch E, Martini M. Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer. Gut. 2023 Feb;72(2):360-371. doi: 10.1136/gutjnl-2021-325117. Epub 2022 May 27. PMID: 35623884; PMCID: PMC9872233.

Meijer JJ, Leonetti A, Airò G, Tiseo M, Rolfo C, Giovannetti E, Vahabi M. Small cell lung cancer: Novel treatments beyond immunotherapy. Semin Cancer Biol. 2022 Nov;86(Pt 2):376-385. doi: 10.1016/j.semcancer.2022.05.004. Epub 2022 May 11. PMID: 35568295.

Anobile DP, Montenovo G, Pecoraro C, Franczak M, Ait Iddouch W, Peters GJ, Riganti C, Giovannetti E. Splicing deregulation, microRNA and notch aberrations: fighting the three-headed dog to overcome drug resistance in malignant mesothelioma. Expert Rev Clin Pharmacol. 2022 Mar;15(3):305-322. doi: 10.1080/17512433.2022.2074835. Epub 2022 May 15. PMID: 35533249.

Bononi G, Di Stefano M, Poli G, Ortore G, Meier P, Masetto F, Caligiuri I, Rizzolio F, Macchia M, Chicca A, Avan A, Giovannetti E, Vagaggini C, Brai A, Dreassi E, Valoti M, Minutolo F, Granchi C, Gertsch J, Tuccinardi T. Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives. J Med Chem. 2022 May 26;65(10):7118-7140. doi: 10.1021/acs.jmedchem.1c01806. Epub 2022 May 6. PMID: 35522977; PMCID: PMC9150076.

Anastasi F, Dilillo M, Pellegrini D, McDonnell LA. Isolation and Proteomic Analysis of Mouse Serum Small Extracellular Vesicles for Individual Subject Analysis. Methods Mol Biol. 2022;2504:41-54. doi: 10.1007/978-1-0716-2341-1_4. PMID: 35467278.

Xavier CPR, Belisario DC, Rebelo R, Assaraf YG, Giovannetti E, Kopecka J, Vasconcelos MH. The role of extracellular vesicles in the transfer of drug resistance competences to cancer cells. Drug Resist Updat. 2022 May;62:100833. doi: 10.1016/j.drup.2022.100833. Epub 2022 Apr 5. PMID: 35429792.

Comandatore A, Balsano R, Immordino B, Arguedas D, Capula M, Baglio SR, Garajovà I, Malapelle U, Morelli L, Giovannetti E. “Depart from evil, and do good”: Turning Axl from uncontrolled tumorigenic gene to biomarker for early detection of pancreatic cancer. Crit Rev Oncol Hematol. 2022 May;173:103659. doi: 10.1016/j.critrevonc.2022.103659. Epub 2022 Apr 6. PMID: 35398264.

Boyaval F, Dalebout H, Van Zeijl R, Wang W, Fariña-Sarasqueta A, Lageveen-Kammeijer GSM, Boonstra JJ, McDonnell LA, Wuhrer M, Morreau H, Heijs B. High-Mannose N-Glycans as Malignant Progression Markers in Early-Stage Colorectal Cancer. Cancers (Basel). 2022 Mar 18;14(6):1552. doi: 10.3390/cancers14061552. PMID: 35326703; PMCID: PMC8945895.

Anobile DP, Niso M, Puerta A, Fraga Rodrigues SM, Abatematteo FS, Avan A, Abate C, Riganti C, Giovannetti E. New Pharmacological Strategies against Pancreatic Adenocarcinoma: The Multifunctional Thiosemicarbazone FA4. Molecules. 2022 Mar 4;27(5):1682. doi: 10.3390/molecules27051682. PMID: 35268783; PMCID: PMC8911630.

Meskers CJW, Franczak M, Smolenski RT, Giovannetti E, Peters GJ. Are we still on the right path(way)?: the altered expression of the pentose phosphate pathway in solid tumors and the potential of its inhibition in combination therapy. Expert Opin Drug Metab Toxicol. 2022 Jan;18(1):61-83. doi: 10.1080/17425255.2022.2049234. Epub 2022 Apr 6. PMID: 35238253.

Comandatore A, Immordino B, Balsano R, Capula M, Garajovà I, Ciccolini J, Giovannetti E, Morelli L. Potential Role of Exosomes in the Chemoresistance to Gemcitabine and Nab-Paclitaxel in Pancreatic Cancer. Diagnostics (Basel). 2022 Jan 23;12(2):286. doi: 10.3390/diagnostics12020286. PMID: 35204377; PMCID: PMC8871170.

Franczak M, Kutryb-Zajac B, El Hassouni B, Giovannetti E, Granchi C, Minutolo F, Smolenski RT, Peters GJ. The effect of lactate dehydrogenase-A inhibition on intracellular nucleotides and mitochondrial respiration in pancreatic cancer cells. Nucleosides Nucleotides Nucleic Acids. 2022;41(12):1375-1385. doi: 10.1080/15257770.2022.2031215. Epub 2022 Feb 7. PMID: 35130822.

Garajová I, Balsano R, Donati V, Gnetti L, Capula M, Leonardi F, Valle RD, Ravaioli M, Gelsomino F, Giovannetti E. Comment on “Implications of Perineural Invasion on Disease Recurrence and Survival After Pancreatectomy for Pancreatic Head Ductal Adenocarcinoma by Crippa et al.”. Ann Surg. 2022 Aug 1;276(2):e136-e137. doi: 10.1097/SLA.0000000000005275. Epub 2021 Nov 11. PMID: 35129485.

Boyd LNC, Ali M, Kam L, Puik JR, Rodrigues SMF, Zwart ES, Daams F, Zonderhuis BM, Meijer LL, Le Large TYS, Giovannetti E, van Laarhoven HWM, Kazemier G. The Diagnostic Value of the CA19-9 and Bilirubin Ratio in Patients with Pancreatic Cancer, Distal Bile Duct Cancer and Benign Periampullary Diseases, a Novel Approach. Cancers (Basel). 2022 Jan 11;14(2):344. doi: 10.3390/cancers14020344. PMID: 35053506; PMCID: PMC8774022.

Rodriguez E, Boelaars K, Brown K, Madunić K, van Ee T, Dijk F, Verheij J, Li RJE, Schetters STT, Meijer LL, Le Large TYS, Driehuis E, Clevers H, Bruijns SCM, O’Toole T, van Vliet SJ, Bijlsma MF, Wuhrer M, Kazemier G, Giovannetti E, Garcia-Vallejo JJ, van Kooyk Y. Analysis of the glyco-code in pancreatic ductal adenocarcinoma identifies glycan-mediated immune regulatory circuits. Commun Biol. 2022 Jan 11;5(1):41. doi: 10.1038/s42003-021-02934-0. PMID: 35017635; PMCID: PMC8752754.

Pecoraro C, Carbone D, Deng D, Cascioferro SM, Diana P, Giovannetti E. Biofilm Formation as Valuable Target to Fight against Severe Chronic Infections. Curr Med Chem. 2022;29(25):4307-4310. doi: 10.2174/0929867329666220103095551. PMID: 34979887.

Costamagna A, Natalini D, Camacho Leal MDP, Simoni M, Gozzelino L, Cappello P, Novelli F, Ambrogio C, Defilippi P, Turco E, Giovannetti E, Hirsch E, Cabodi S, Martini M. Docking Protein p130Cas Regulates Acinar to Ductal Metaplasia During Pancreatic Adenocarcinoma Development and Pancreatitis. Gastroenterology. 2022 Apr;162(4):1242-1255.e11. doi: 10.1053/j.gastro.2021.12.242. Epub 2021 Dec 17. PMID: 34922945.

Cabiati M, Salvadori C, Basta G, Del Turco S, Aretini P, Cecchettini A, Del Ry S. miRNA and long non-coding RNA transcriptional expression in hepatocellular carcinoma cell line-secreted extracellular vesicles. Clin Exp Med. 2022 May;22(2):245-255. doi: 10.1007/s10238-021-00744-6. Epub 2021 Jul 28. PMID: 34319456.

Supadmanaba IGP, Mantini G, Randazzo O, Capula M, Muller IB, Cascioferro S, Diana P, Peters GJ, Giovannetti E. Interrelationship between miRNA and splicing factors in pancreatic ductal adenocarcinoma. Epigenetics. 2022 Apr;17(4):381-404. doi: 10.1080/15592294.2021.1916697. Epub 2021 May 30. PMID: 34057028; PMCID: PMC8993068.

Boyd LNC, Andini KD, Peters GJ, Kazemier G, Giovannetti E. Heterogeneity and plasticity of cancer-associated fibroblasts in the pancreatic tumor microenvironment. Semin Cancer Biol. 2022 Jul;82:184-196. doi: 10.1016/j.semcancer.2021.03.006. Epub 2021 Mar 15. PMID: 33737108.

Musetti V, Greco F, Castiglione V, Aimo A, Palmieri C, Genovesi D, Giorgetti A, Emdin M, Vergaro G, McDonnell LA, Pucci A. Tissue Characterization in Cardiac Amyloidosis. Biomedicines. 2022 10:3054. doi: 10.3390/biomedicines10123054. PMID: 36551810.

2021

Anastasi F, Dilillo M, Pellegrini D, McDonnell LA. Isolation and Proteomic Analysis of Mouse Serum Small Extra Cellular Vesicles for Individual Subject Analysis. In Extracellular Vesicles in Diagnosis and Therapy. Ed. Federico M and Ridolfi B. Methods in Molecular Biology, Springer-Verlag, New York. In press. ISBN: 978-1-0716-2340-4. In press.

Randazzo O, Cascioferro SM, Pecoraro C, Iddouch WA, Avan A, Parrino B, Carbone D, Perricone U, Peters GJ, Diana P, Giovannetti E. SF3B1 modulators affect key genes in metastasis and drug influx: a new approach to fight pancreatic cancer chemoresistance. Cancer Drug Resist. 2021 Oct 8;4(4):904-922. doi: 10.20517/cdr.2021.61. eCollection 2021.PMID: 35582381 Free PMC article.

Pecoraro C, Parrino B, Cascioferro S, Puerta A, Avan A, Peters GJ, Diana P, Giovannetti E, Carbone D. A New Oxadiazole-Based Topsentin Derivative Modulates Cyclin-Dependent Kinase 1 Expression and Exerts Cytotoxic Effects on Pancreatic Cancer Cells. Molecules. 2021 Dec 21;27(1):19. doi: 10.3390/molecules27010019. PMID: 35011251 Free PMC article.

Barravecchia I, De Cesari C, Forcato M, Scebba F, Pyankova OV, Bridger JM, Foster HA, Signore G, Borghini A, Andreassi M, Andreazzoli M, Bicciato S, Pè ME, Angeloni D. Microgravity and space radiation inhibit autophagy in human capillary endothelial cells, through either opposite or synergistic effects on specific molecular pathways. Cell Mol Life Sci. 2021 Dec 22;79(1):28. doi: 10.1007/s00018-021-04025-z. PMID: 34936031

Costamagna A, Natalini D, Camacho Leal MDP, Simoni M, Gozzelino L, Cappello P, Novelli F, Ambrogio C, Defilippi P, Turco E, Giovannetti E, Hirsch E, Cabodi S, Martini M. Docking Protein p130Cas Regulates Acinar to Ductal Metaplasia During Pancreatic Adenocarcinoma Development and Pancreatitis. Gastroenterology. 2022 Apr;162(4):1242-1255.e11. doi: 10.1053/j.gastro.2021.12.242. Epub 2021 Dec 17. PMID: 34922945

Storti B, Quaranta P, Di Primio C, Clementi N, Mancini N, Criscuolo E, Spezia PG, Carnicelli V, Lottini G, Paolini E, Freer G, Lai M, Costa M, Beltram F, Diaspro A, Pistello M, Zucchi R, Bianchini P, Signore G, Bizzarri R. A spatial multi-scale fluorescence microscopy toolbox discloses entry checkpoints of SARS-CoV-2 variants in Vero E6 cells. Comput Struct Biotechnol J. 2021;19:6140-6156. doi: 10.1016/j.csbj.2021.10.038. Epub 2021 Nov 2. PMID: 34745450 Free PMC article.

Addeo A, Friedlaender A, Giovannetti E, Russo A, de Miguel-Perez D, Arrieta O, Cardona AF, Rolfo C. A New Generation of Vaccines in the Age of Immunotherapy. Curr Oncol Rep. 2021 Nov 4;23(12):137. doi: 10.1007/s11912-021-01130-x. PMID: 34735649 Free PMC article. Review.

Parisi F, Muscatello LV, Civita P, Lessi F, Menicagli M, Millanta F, Brunetti B, Benazzi C, Sarli G, Freer G, Pistello M, Mazzanti CM, Poli A. Pathological Features and Molecular Phenotype of MMTV Like-Positive Feline Mammary Carcinomas. Animals. (Basel), 2021 27;11(10):2821. doi: 10.3390/ani11102821. PMID: 34679842 Free PMC article.

Meneghetti N, Cerri C, Tantillo E, Vannini E, Caleo M, Mazzoni A. Narrow and Broad γ Bands Process Complementary Visual Information in Mouse Primary Visual Cortex. eNeuro. 2021 Nov 4;8(6):ENEURO.0106-21.2021. doi: 10.1523/ENEURO.0106-21.2021. Print 2021 Nov-Dec. PMID: 34663617 Free PMC article.

Greco F, Anastasi F, Pardini LF, Dilillo M, Vannini E, Baroncelli L, Caleo M, McDonnell LA. Longitudinal Bottom-Up Proteomics of Serum, Serum Extracellular Vesicles, and Cerebrospinal Fluid Reveals Candidate Biomarkers for Early Detection of Glioblastoma in a Murine Model. Molecules. 2021 Oct 2;26(19):5992. doi: 10.3390/molecules26195992. PMID: 34641541 Free PMC article.

Leonetti A, Giudice GC, Perrone F, Tiseo M, Giovannetti E. Letter comments on: The effects of antibiotics on the efficacy of immune-checkpoint inhibitors in non-small cell lung cancer patients differ according to PD-L1 expression. Eur J Cancer. 2021 Nov;157:520-522. doi: 10.1016/j.ejca.2021.07.043. Epub 2021 Sep 6. PMID: 34503886 No abstract available.

Wijnen R, Pecoraro C, Carbone D, Fiuji H, Avan A, Peters GJ, Giovannetti E, Diana P. Cyclin Dependent Kinase-1 (CDK-1) Inhibition as a Novel Therapeutic Strategy against Pancreatic Ductal Adenocarcinoma (PDAC). Cancers (Basel). 2021 Aug 30;13(17):4389. doi: 10.3390/cancers13174389. PMID: 34503199 Free PMC article. Review.

Pecoraro C, Faggion B, Balboni B, Carbone D, Peters GJ, Diana P, Assaraf YG, Giovannetti E. GSK3β as a novel promising target to overcome chemoresistance in pancreatic cancer. Drug Resist Updat. 2021 Sep;58:100779. doi: 10.1016/j.drup.2021.100779. Epub 2021 Aug 12. PMID: 34461526 Review.

Papini F, Sundaresan J, Leonetti A, Tiseo M, Rolfo C, Peters GJ, Giovannetti E. Hype or hope – Can combination therapies with third-generation EGFR-TKIs help overcome acquired resistance and improve outcomes in EGFR-mutant advanced/metastatic NSCLC? Crit Rev Oncol Hematol. 2021 Oct;166:103454. doi: 10.1016/j.critrevonc.2021.103454. Epub 2021 Aug 26. PMID: 34455092 Review.

Castiglione V, Modena M, Aimo A, Chiti E, Botto N, Vittorini S, Guidi B, Vergaro G, Barison A, Rossi A, Passino C, Giannoni A, Di Paolo M, Emdin M. Molecular Autopsy of Sudden Cardiac Death in the Genomics Era. Diagnostics (Basel). 2021 Jul 30;11(8):1378. doi: 10.3390/diagnostics11081378. PMID: 34441312 Free PMC article. Review.

Casolino R, Biankin AV; PanCaCovid-19 Study Group. Impact of COVID-19 on Pancreatic Cancer Research and the Path Forward. Gastroenterology. 2021 Dec;161(6):1758-1763. doi: 10.1053/j.gastro.2021.06.080. Epub 2021 Aug 10. PMID: 34389342 Free PMC article. No abstract available.

Bodini A, Michelucci E, Di Giorgi N, Caselli C, Signore G, Neglia D, Smit JM, Scholte AJHA, Mincarone P, Leo CG, Pelosi G, Rocchiccioli S. Predictive Added Value of Selected Plasma Lipids to a Re-estimated Minimal Risk Tool. Front Cardiovasc Med. 2021 Jul 16;8:682785. doi: 10.3389/fcvm.2021.682785. eCollection 2021. PMID: 34336947 Free PMC article.

Cabiati M, Salvadori C, Basta G, Del Turco S, Aretini P, Cecchettini A, Del Ry S miRNA and long non-coding RNA transcriptional expression in hepatocellular carcinoma cell line-secreted extracellular vesicles. Clin Exp Med. 2021 Jul 28. doi: 10.1007/s10238-021-00744-6. Online ahead of print. PMID: 34319456

Noberini R, Savoia EO, Brandini S, Greco F, Marra F, Bertalot G, Pruneri G, McDonnell LA, Bonaldi T. Spatial epi-proteomics enabled by histone post-translational modification analysis from low-abundance clinical samples. Clin Epigenetics. 2021 Jul 28;13(1):145. doi: 10.1186/s13148-021-01120-7. PMID: 34315505 Free PMC article.

Guglielmi C, Scarpitta R, Gambino G, Conti E, Bellè F, Tancredi M, Cervelli T, Falaschi E, Cosini C, Aretini P, Congregati C, Marino M, Patruno M, Pilato B, Spina F, Balestrino L, Tenedini E, Carnevali I, Cortesi L, Tagliafico E, Tibiletti MG, Tommasi S, Ghilli M, Vivanet C, Galli A, Caligo MA. Detection of Germline Variants in 450 Breast/Ovarian Cancer Families with a Multi-Gene Panel Including Coding and Regulatory Regions. Int J Mol Sci. 2021 Jul 19;22(14):7693. doi: 10.3390/ijms22147693. PMID: 34299313 Free PMC article.

Castaño J, Romero-Moya D, Richaud-Patin Y, Giorgetti A Generation of two heterozygous GATA2 CRISPR/Cas9-edited iPSC lines, R398W and R396Q, for modeling GATA2 deficiency. Stem Cell Res. 2021 Aug;55:102445. doi: 10.1016/j.scr.2021.102445. Epub 2021 Jun 27. PMID: 34284273

Domenici L, Tonacci A, Aretini P, Garibaldi S, Perutelli A, Bottone P, Muzii L, Benedetti Panici P. Inflammatory Biomarkers as Promising Predictors of Prognosis in Cervical Cancer Patients. Oncology. 2021;99(9):571-579. doi: 10.1159/000517320. Epub 2021 Jul 15. PMID: 34265768

Le Large TYS, Boyd LNC, Kazemier G, Giovannetti E. The Proteomic Landscape of Pancreatic Ductal Adenocarcinoma Liver Metastases Identifies Molecular Subtypes and Associations with Clinical Response. Clin Cancer Res. 2021 Jul 15;27(14):4126. doi: 10.1158/1078-0432.CCR-21-0775. PMID: 34261771.

Leonetti A, Capula M, Minari R, Mazzaschi G, Gregori A, El Hassouni B, Papini F, Bordi P, Verzè M, Avan A, Tiseo M, Giovannetti E. Dynamic Evaluation of Circulating miRNA Profile in EGFR-Mutated NSCLC Patients Treated with EGFR-TKIs. Cells. 2021 Jun 16;10(6):1520. doi: 10.3390/cells10061520. PMID: 34208765 Free PMC article.

Giovannetti E, Peters G. Beyond animal models: implementing the 3Rs principles and improving pharmacological studies with new model systems. Expert Opin Drug Metab Toxicol. 2021 Aug;17(8):867-868. doi: 10.1080/17425255.2021.1948731. Epub 2021 Jun 30. PMID: 34170804 No abstract available.

Lessi F, Aretini P, Rizzo M, Morelli M, Menicagli M, Franceschi S, Mazzanti CM. Analysis of exosome-derived microRNAs reveals insights of intercellular communication during invasion of breast, prostate and glioblastoma cancer cells. Cell Adh Migr. 2021 Dec;15(1):180-201. doi: 10.1080/19336918.2021.1935407. PMID: 34157951 Free PMC article.

Michelucci E, Giorgi ND, Finamore F, Smit JM, Scholte AJHA, Signore G, Rocchiccioli S. Lipid biomarkers in statin users with coronary artery disease annotated by coronary computed tomography angiography. Sci Rep. 2021 Jun 18;11(1):12899. doi: 10.1038/s41598-021 92339-0. PMID: 34145378 Free PMC article.

Montemurro N, Fanelli GN, Scatena C, Ortenzi V, Pasqualetti F, Mazzanti CM, Morganti R, Paiar F, Naccarato AG, Perrini P. Surgical outcome and molecular pattern characterization of recurrent glioblastoma multiforme: A single-center retrospective series. Clin Neurol Neurosurg. 2021 Aug;207:106735. doi: 10.1016/j.clineuro.2021.106735. Epub 2021 Jun 8. PMID: 34119900.

Gentile P, Bernini M, Orzalesi L, Sordi S, Meattini I, Lessi F, Kothari A, Calabrese C. Titanium-coated polypropylene mesh as innovative bioactive material in conservatives mastectomies and pre-pectoral breast reconstruction. Bioact Mater. 2021 May 19;6(12):4640-4653. doi: 10.1016/j.bioactmat.2021.05.002. eCollection 2021 Dec. PMID: 34095622 Free PMC article.

Moretti G, Aretini P, Lessi F, Mazzanti CM, Ak G, Metintaş M, Lando C, Filiberti RA, Lucchi M, Bonotti A, Foddis R, Cristaudo A, Bottari A, Apollo A, Del Re M, Danesi R, Mutti L, Gemignani F, Landi S. Liquid Biopsies from Pleural Effusions and Plasma from Patients with Malignant Pleural Mesothelioma: A Feasibility Study. Cancers (Basel). 2021 May 18;13(10):2445. doi: 10.3390/cancers13102445. PMID: 34070018 Free PMC article.

Finamore F, Cecchettini A, Ceccherini E, Signore G, Ferro F, Rocchiccioli S, Baldini C. Characterization of Extracellular Vesicle Cargo in Sjögren’s Syndrome through a SWATH-MS Proteomics Approach. Int J Mol Sci. 2021 May 4;22(9):4864. doi: 10.3390/ijms22094864. PMID: 34064456 Free PMC article.

Supadmanaba IGP, Mantini G, Randazzo O, Capula M, Muller IB, Cascioferro S, Diana P, Peters GJ, Giovannetti E. Interrelationship between miRNA and splicing factors in pancreatic ductal adenocarcinoma. Epigenetics. 2021 May 30:1-24. doi: 10.1080/15592294.2021.1916697. Online ahead of print. PMID: 34057028.

Vozzi F, Cecchettini A, Cabiati M, Mg F, Aretini P, Del Ry S, Rocchiccioli S, Pelosi G. Modulated molecular markers of restenosis and thrombosis byin-vitrovascular cells exposed to bioresorbable scaffolds. Biomed Mater. 2021 Jun 16;16(4). doi: 10.1088/1748-605X/ac0401. PMID: 34020430.

Supadmanaba IGP, Comandatore A, Morelli L, Giovannetti E, Lagerweij T. Organotypic-liver slide culture systems to explore the role of extracellular vesicles in pancreatic cancer metastatic behavior and guide new therapeutic approaches. Expert Opin Drug Metab Toxicol. 2021 Aug;17(8):937-946. doi: 10.1080/17425255.2021.1925646. Epub 2021 May 21. PMID: 33945374 Review.

Franceschi S, Civita P, Pasqualetti F, Lessi F, Modena M, Barachini S, Morelli M, Santonocito O, Vannozzi R, Pilkington GJ, Ortenzi V, Naccarato AG, Aretini P, Mazzanti CM. Multiregional Sequencing of IDH-WT Glioblastoma Reveals High Genetic Heterogeneity and a Dynamic Evolutionary History. Cancers (Basel). 2021 Apr 23;13(9):2044. doi: 10.3390/cancers13092044. PMID: 33922652 Free PMC article.

Greco F, Quercioli L, Pucci A, Rocchiccioli S, Ferrari M, Recchia FA, McDonnell LA. Mass Spectrometry Imaging as a Tool to Investigate Region Specific Lipid Alterations in Symptomatic Human Carotid Atherosclerotic Plaques. Metabolites. 2021 Apr 18;11(4):250. doi: 10.3390/metabo11040250. PMID: 33919525 Free PMC article.

Leonetti A, Carbone D, Gregori A, Tiseo M, Peters GJ, Deng D, Giovannetti E. A bug in the resistance to EGFR inhibitors: is there a role for Mycoplasma and cytidine deaminase in reducing the activity of osimertinib in lung cancer patients? J Cancer Res Clin Oncol. 2021 Oct;147(10):3135-3137. doi: 10.1007/s00432-021-03647-x. Epub 2021 Apr 26. PMID: 33900435.

Anastasi F, Masciandaro SM, Carratore RD, Dell’Anno MT, Signore G, Falleni A, McDonnell LA, Bongioanni P. Proteomics Profiling of Neuron-Derived Small Extracellular Vesicles from Human Plasma: Enabling Single-Subject Analysis. Int J Mol Sci. 2021 Mar 14;22(6):2951. doi: 10.3390/ijms22062951. PMID: 33799461 Free PMC article.

Le Large TYS, Bijlsma MF, El Hassouni B, Mantini G, Lagerweij T, Henneman AA, Funel N, Kok B, Pham TV, de Haas R, Morelli L, Knol JC, Piersma SR, Kazemier G, van Laarhoven HWM, Giovannetti E, Jimenez CR. Focal adhesion kinase inhibition synergizes with nab-paclitaxel to target pancreatic ductal adenocarcinoma. J Exp Clin Cancer Res. 2021 Mar 9;40(1):91. doi: 10.1186/s13046-021-01892-z. PMID: 33750427 Free PMC article.

Boyd LNC, Andini KD, Peters GJ, Kazemier G, Giovannetti E. Heterogeneity and plasticity of cancer-associated fibroblasts in the pancreatic tumor microenvironment. Semin Cancer Biol. 2021 Mar 15:S1044-579X(21)00056-0. doi: 10.1016/j.semcancer.2021.03.006. Online ahead of print. PMID: 33737108

Di Pietro S, Iacopini D, Moscardini A, Bizzarri R, Pineschi M, Di Bussolo V, Signore G. New Coumarin Dipicolinate Europium Complexes with a Rich Chemical Speciation and Tunable Luminescence. Molecules. 2021 Feb 26;26(5):1265. doi: 10.3390/molecules26051265. PMID: 33652775 Free PMC article.

Rodriguez E, Boelaars K, Brown K, Eveline Li RJ, Kruijssen L, Bruijns SCM, van Ee T, Schetters STT, Crommentuijn MHW, van der Horst JC, van Grieken NCT, van Vliet SJ, Kazemier G, Giovannetti E, Garcia-Vallejo JJ, van Kooyk Y. Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9. Nat Commun. 2021 Feb 24;12(1):1270. doi: 10.1038/s41467-021-21550-4. PMID: 33627655 Free PMC article.

Mapanao AK, Che PP, Sarogni P, Sminia P, Giovannetti E, Voliani V. Tumor grafted – chick chorioallantoic membrane as an alternative model for biological cancer research and conventional/nanomaterial-based theranostics evaluation. Expert Opin Drug Metab Toxicol. 2021 Aug;17(8):947-968. doi: 10.1080/17425255.2021.1879047. Epub 2021 Feb 10. PMID: 33565346 Review.

Pasqualetti F, Gonnelli A, Orlandi P, Palladino E, Giannini N, Gadducci G, Mattioni R, Montrone S, Calistri E, Mazzanti CM, Franceschi S, Ortenzi V, Scatena C, Zavaglia K, Fanelli GN, Morganti R, Santonocito O, Bocci G, Naccarato GA, Paiar F. Association of XRCC3 rs1799794 polymorphism with survival of glioblastoma multiforme patients treated with combined radio-chemotherapy. Invest New Drugs. 2021 Aug;39(4):1159-1165. doi: 10.1007/s10637-021-01075-9. Epub 2021 Feb 8. PMID: 33558989.

Perutelli A, Ferrandina G, Domenici L, Cubeddu A, Garibaldi S, Aretini P, Mazzanti CM, Salerno MG. Modified intestinal isolation bag as promising tool in promoting bowel resumption after ovarian cancer cytoreductive surgery: a randomized clinical trial. Arch Gynecol Obstet. 2021 Sep;304(3):733-742. doi: 10.1007/s00404-021-05981-4. Epub 2021 Feb 8. PMID: 33555430 Clinical Trial.

Scatena C, Fanelli G, Fanelli GN, Menicagli M, Aretini P, Ortenzi V, Civitelli SP, Innocenti L, Sotgia F, Lisanti MP, Naccarato AG. New insights in the expression of stromal caveolin 1 in breast cancer spread to axillary lymph nodes. Sci Rep. 2021 Feb 2;11(1):2755. doi: 10.1038/s41598-021-82405-y. PMID: 33531603 Free PMC article.

Moosavi F, Giovannetti E, Peters GJ, Firuzi O. Combination of HGF/MET-targeting agents and other therapeutic strategies in cancer. Crit Rev Oncol Hematol. 2021 Apr;160:103234. doi: 10.1016/j.critrevonc.2021.103234. Epub 2021 Jan 23. PMID: 33497758 Review.

Migliorini F, Maffulli N, Aretini P, Trivellas A, Tingart M, Eschweiler J, Baroncini A. Impact of tourniquet during knee arthroplasty: a bayesian network meta-analysis of peri-operative outcomes.  Arch Orthop Trauma Surg. 2021 Jun;141(6):1007-1023. doi: 10.1007/s00402-020-03725-8. Epub 2021 Jan 8. PMID: 33417033 Free PMC article.

El Hassouni B, Gregori A, Puik JR, Deng D, Kazemier G, Giovannetti E. Antibiotics and Adverse Events in Patients with Pancreatic Cancer Treated with Gemcitabine: Looking for Novel Clinical and Preclinical Insights. Oncologist. 2021 Dec;26(12):e2306-e2307. doi: 10.1002/onco.13606. Epub 2020 Dec 7. PMID: 33230870 Free PMC article.

Agostini M, Amato F, Vieri ML, Greco G, Tonazzini I, Baroncelli L, Caleo M, Vannini E, Santi M, Signore G, Cecchini M. Glial-fibrillary-acidic-protein (GFAP) biomarker detection in serum-matrix: Functionalization strategies and detection by an ultra-high-frequency surface-acoustic-wave (UHF-SAW) lab-on-chip. Biosens Bioelectron. 2021 Jan 15;172:112774. doi: 10.1016/j.bios.2020.112774. Epub 2020 Oct 31. PMID: 33160234.

Carbone D, Parrino B, Cascioferro S, Pecoraro C, Giovannetti E, Di Sarno V, Musella S, Auriemma G, Cirrincione G, Diana P. 1,2,4-Oxadiazole Topsentin Analogs with Antiproliferative Activity against Pancreatic Cancer Cells, Targeting GSK3β Kinase. ChemMedChem. 2021 Feb 4;16(3):537-554. doi: 10.1002/cmdc.202000752. Epub 2020 Nov 3. PMID: 33141472.

Cascioferro S, Carbone D, Parrino B, Pecoraro C, Giovannetti E, Cirrincione G, Diana P. Therapeutic Strategies To Counteract Antibiotic Resistance in MRSA Biofilm-Associated Infections. ChemMedChem. 2021 Jan 8;16(1):65-80. doi: 10.1002/cmdc.202000677. Epub 2020 Nov 6. PMID: 33090669 Review.

Granchi C, Bononi G, Ferrisi R, Gori E, Mantini G, Glasmacher S, Poli G, Palazzolo S, Caligiuri I, Rizzolio F, Canzonieri V, Perin T, Gertsch J, Sodi A, Giovannetti E, Macchia M, Minutolo F, Tuccinardi T, Chicca A. Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors. Eur J Med Chem. 2021 Jan 1;209:112857. doi: 10.1016/j.ejmech.2020.112857. Epub 2020 Oct 7. PMID: 33045662.

Parrino B, Carbone D, Cascioferro S, Pecoraro C, Giovannetti E, Deng D, Di Sarno V, Musella S, Auriemma G, Cusimano MG, Schillaci D, Cirrincione G, Diana P. 1,2,4-Oxadiazole topsentin analogs as staphylococcal biofilm inhibitors targeting the bacterial transpeptidase sortase A. Eur J Med Chem. 2021 Jan 1;209:112892. doi: 10.1016/j.ejmech.2020.112892. Epub 2020 Sep 29. PMID: 33035921.

Migliorini F, Trivellas A, Eschweiler J, Driessen A, Lessi F, Tingart M, Aretini P. Nerve palsy, dislocation and revision rate among the approaches for total hip arthroplasty: a Bayesian network meta-analysis. Musculoskelet Surg. 2021 Apr;105(1):1-15. doi: 10.1007/s12306-020-00662-y. Epub 2020 May 5. PMID: 32372300

2020

Differential roles of pyramidal and fast-spiking, GABAergic neurons in the control of glioma cell proliferation. Tantillo E, Vannini E, Cerri C, Spalletti C, Colistra A, Mazzanti CM, Costa M, Caleo M. Neurobiol Dis. 2020 Jul;141:104942. doi: 10.1016/j.nbd.2020.104942. Epub 2020 May 11

Diffuse bone and soft tissue angiomatosis with GNAQ mutation. Gaeta R, Lessi F, Mazzanti CM, Modena M, Garaventa A, Boero S, Michelis MB, Capanna R, Aretini P, Franchi A. Pathol Int. 2020 Jul;70(7):452-457. Epub 2020 Apr 20. doi: 10.1111/pin.12933. Epub 2020 Apr 20

Unveiling a sudden unexplained death case by whole exome sequencing and bioinformatic analysis. Modena M, Castiglione V, Aretini P, Mazzanti CM, Chiti E, Giannoni A, Emdin M, Di Paolo M. Mol Genet Genomic Med. 2020 Apr;8(4):e1182. doi: 10.1002/mgg3.1182. Epub 2020 Feb 26

Whole exome sequencing in familial isolated primary hyperparathyroidism. Cetani F, Pardi E, Aretini P, Saponaro F, Borsari S, Mazoni L, Apicella M, Civita P, La Ferla M, Caligo MA, Lessi F, Mazzanti CM, Torregossa L, Oppo A, Marcocci C. J Endocrinol Invest. 2020 Feb;43(2):231-245. doi: 10.1007/s40618-019-01107-5. Epub 2019 Sep 5

Hospitalization length, surgical duration, and blood lost among the approaches for total hip arthroplasty: a Bayesian network meta-analysis. Migliorini F, Trivellas A, Eschweiler J, El Mansy Y, Mazzanti MC, Tingart M, Aretini P. Musculoskelet Surg. 2020 Dec;104(3):257-266. doi: 10.1007/s12306-020-00657-9. Epub 2020 Apr 4

A human MMTV-like betaretrovirus linked to breast cancer has been present in humans at least since the copper age. Lessi F, Grandi N, Mazzanti CM, Civita P, Scatena C, Aretini P, Bandiera P, Fornaciari A, Giuffra V, Fornaciari G, Naccarato AG, Tramontano E, Bevilacqua G. Aging (Albany NY). 2020 Jul 31;12(16):15978-15994. doi: 10.18632/aging.103780. Epub 2020 Jul 31

Human Mammary Tumor Virus, Human Papilloma Virus, and Epstein-Barr Virus Infection Are Associated With Sporadic Breast Cancer Metastasis. Al Hamad M, Matalka I, Al Zoubi MS, Armogida I, Khasawneh R, Al-Husaini M, Sughayer M, Jaradat S, Al-Nasser AD, Mazzanti CM. Breast Cancer (Auckl). 2020 Nov 24;14:1178223420976388. doi: 10.1177/1178223420976388

Coumarin-based fluorescent biosensor with large linear range for ratiometric measurement of intracellular pH. Iacopini D, Moscardini A, Lessi F, Di Bussolo V, Di Pietro S, Signore G. Bioorg Chem. 2020 Dec;105:104372. doi: 10.1016/j.bioorg.2020.104372. Epub 2020 Oct 12

Nerve palsy, dislocation and revision rate among the approaches for total hip arthroplasty: a Bayesian network meta-analysis. Migliorini F, Trivellas A, Eschweiler J, Driessen A, Lessi F, Tingart M, Aretini P. Musculoskelet Surg. 2020 May 5. doi: 10.1007/s12306-020-00662-y. PMID: 32372300 Review

Better outcomes after mini-subvastus approach for primary total knee arthroplasty: a Bayesian network meta-analysis. Migliorini F, Aretini P, Driessen A, El Mansy Y, Quack V, Tingart M, Eschweiler. J. Eur J Orthop Surg Traumatol. 2020 Aug;30(6):979-992. doi: 10.1007/s00590-020-02648-9. Epub 2020 Mar 10. PMID: 32152747 Review

Implant positioning among the surgical approaches for total hip arthroplasty: a Bayesian network meta-analysis. Migliorini F, Eschweiler J, Trivellas A, Rath B, Driessen A, Tingart M, Aretini P. Arch Orthop Trauma Surg. 2020 Aug;140(8):1115-1124. doi: 10.1007/s00402-020-03448-w. Epub 2020 May 2

Protein delivery by peptide-based stealth liposomes: a biomolecular insight into enzyme replacement therapy. Mol Pharm. Santi M, Finamore F, Cecchettini A, Santorelli FM, Doccini S, Rocchiccioli S, Signore G. 2020 Dec 7;17(12):4510-4521. doi: 10.1021/acs.molpharmaceut.0c00615

Morphological and Elastic Transition of Polystyrene Adsorbed Layers on Silicon Oxide. Dinelli F, Pingue P, Signore G, Napolitano S. J. Micr.2020 Aug 14;280:280-286 doi: 10.1111/jmi.12954

An objective, principal-component-analysis (PCA) based, method which improves the quartz-crystal-microbalance (QCM) sensing performance. Corradi E, Agostini M, Greco G, Massidda D, Santi M, Calderisi M, Signore G, Cecchini M. Sens. Act. A: Physical 2020 Nov 1;315: 112323 doi: 10.1016/j.sna.2020.112323

Proteomics pipeline for phosphoenrichment and its application on a human melanoma cell model. Finamore F, Ucciferri N, Signore G, Cecchettini A, Ceccherini E, Vitiello M, Poliseno L, Rocchiccioli S. Talanta. 2020 Dec 1;220:121381 doi: 10.1016/j.talanta.2020.121381

Fluorolabeling of the PPTase-Related Chemical Tags: Comparative Study of Different Membrane Receptors and Different Fluorophores in the Labeling Reactions. Amodeo R, Convertino D, Calvello M, Ceccarelli L, Bonsignore F, Ravelli C, Cattaneo A, Martini C, Luin S, Mitola S, Signore G, Marchetti L. Front Mol Biosci. 2020 Aug 7;7:195 doi: 10.3389/fmolb.2020.00195

Uranium‑free X solution: a new generation contrast agent for biological samples ultrastructure. Moscardini A, Di Pietro S, Signore G, Parlanti P, Santi M, Gemmi M, Cappello V. Sci Rep. 2020 Jul 14;10(1):11540 doi: /10.1038/s41598-020-68405-4

Targeted Dendrimer-Coated Magnetic Nanoparticles for Selective Delivery of Therapeutics in Living Cells. Parlanti P, Boni A, Signore G, Santi M. Molecules. 2020 May 10;25(9):2252 doi:10.3390/molecules25092252

Proteomic and functional analyses in disease models reveal CLN5 protein involvement in mitochondrial dysfunction. Doccini S, Morani F, Nesti C, Pezzini F, Calza G, Soliymani R, Signore G, Rocchiccioli S, Kanninen KM, Huuskonen MT, Baumann MH, Simonati A, Lalowski MM, Santorelli FM. Cell Death Discov. 2020 Mar 30;6:18 doi: 10.1038/s41420-020-0250-y

New 1,3-Disubstituted Benzo[h]Isoquinoline Cyclen-Based Ligand Platform: Synthesis, Eu3+ Multiphoton Sensitization and Imaging Applications. Di Pietro S, Iacopini D, Storti B, Nifosì R, Di Bussolo V, Pineschi M, Moscardini A, Signore G, Bizzarri R. Molecules. 2020 Dec 24;26(1):58 doi: 10.3390/molecules26010058

Glial-fibrillary-acidic-protein (GFAP) biomarker detection in serum-matrix: Functionalization strategies and detection by an ultra-high-frequency surface-acoustic-wave (UHF-SAW) lab-on-chip. Agostini M, Amato F, Vieri ML, Greco G, Tonazzini I, Baroncelli L, Caleo M, Vannini E, Santi M, Signore G, Cecchini M. Biosensors and Bioelectronics. 2021; 172:112774 doi: 10.1016/j.bios.2020.112774

Synaptic Vesicles Dynamics in Neocortical Epilepsy. Vannini E, Restani L, Dilillo M, McDonnell LA, Caleo M, Marra V. Front Cell Neurosci. 2020 Dec 10;14:606142, doi.org/10.3389/fncel.2020.606142

rMSIproc: an R package for mass spectrometry imaging data processing. Ràfols P, Heijs B, Del Castillo E, Yanes O, McDonnell LA, Brezmes J, Pérez-Taboada I, Vallejo M, García-Altares M, Correig X. Bioinformatics. 2020 Jun 1;36(11):3618-3619 doi.org/10.1093/bioinformatics/btaa142

Molecular signatures of tumor progression in myxoid liposarcoma identified by N-glycan mass spectrometry imaging. Heijs B, Holst-Bernal S, de Graaff MA, Briaire-de Bruijn IH, Rodriguez-Girondo M, van de Sande MAJ, Wuhrer M, McDonnell LA, Bovée JVMG. Lab Invest. 2020 Sep;100(9):1252-1261 doi: 10.1038/s41374-020-0435-2

Proteomics analysis of serum small extracellular vesicles for the longitudinal study of a glioblastoma multiforme mouse model. Anastasi F, Greco F, Dilillo M, Vannini E, Cappello V, Baroncelli L, Costa M, Gemmi M, Caleo M, McDonnell LA. Sci Rep. 2020 Nov 24;10(1):20498 doi: 10.1038/s41598-020-77535-8

Human Neural Stem Cell Systems to Explore Pathogen-Related Neurodevelopmental and Neurodegenerative Disorders. Baggiani M, Dell’Anno MT*, Pistello M, Conti L, Onorati M.(* co-first author). Cells, 2020 Aug 12;9(8):1893 doi: 10.3390/cells9081893

Omics Analysis of Educated Platelets in Cancer and Benign Disease of the Pancreas. Mantini G, Meijer LL, Glogovitis I, In’t Veld Sjors GJG, Paleckyte R, Capula M, Le Large Tessa YS, Morelli L, Pham TV, Piersma SR, Frampton AE, Jimenez CR, Kazemier G, Koppers-Lalic D, Wurdinger, Giovannetti E. Cancers 2020 Dec 29;13(1):66 doi.org/10.3390/cancers13010066

Co-expression analysis of pancreatic cancer proteome reveals biology and prognostic biomarkers. Mantini G, Valles AM, Le Large TYS, Capula M, Funel N, Pham TV, Piersma SR, Kazemier G, Bijlsma MF, Giovannetti E,* Jimenez CR.* (*equally contributed). Cell Oncol 2020 Dec;43(6):1147-1159 doi: 10.1007/s13402-020-00548-y

Microdissected pancreatic cancer proteomes reveal tumor heterogeneity and therapeutic targets. Le LargeTYS, Mantini G, Meijer LL, Pham TV, Funel N, van Grieken NCT, Knol J, van Laarhoven HWM, Piersma SR, Jimenez CR, Kazemier G, Giovannetti E,* Bijlsma MF.* (*equally contributed). JCI Insight 2020 Aug 6;5(15):e138290 doi: 10.1172/jci.insight.138290

Antibiotics and Adverse Events in Pancreatic Cancer Patients Treated with Gemcitabine: Looking for Novel Clinical and Preclinical Insights. El Hassouni B, Gregori A, Puik JR, Deng D, Kazemier G, Giovannetti E. Oncologist. 2020 Nov 23 doi: 10.1002/onco.13606. Online ahead of print

Lactate dehydrogenase A inhibition by small molecular entities: steps in the right direction. El Hassouni B, Franczak M, Capula M, Vonk CM, Gomez VM, Smolenski RT, Granchi C, Peters GJ, Minutolo F, Giovannetti E. Oncoscience. 2020 Sep 9;7(9-10):76-80 doi: 10.18632/oncoscience.519. eCollection

Epithelial Transfer of the Tyrosine Kinase Inhibitors Erlotinib, Gefitinib, Afatinib, Crizotinib, Sorafenib, Sunitinib, and Dasatinib: Implications for Clinical Resistance. Honeywell RJ, Kathmann I, Giovannetti E, Tibaldi C, Smit EF, Rovithi MN, Verheul HMW, Peters GJ. Cancers (Basel). 2020 Nov 10;12(11):3322 doi: 10.3390/cancers12113322

The Role of Circular RNAs in Pancreatic Ductal Adenocarcinoma and Biliary-Tract Cancers. Limb C, Liu DSK, Veno MT, Rees E, Krell J, Bagwan IN, Giovannetti E, Pandha H, Strobel S, Rockall TA, Frampton AE. Cancers 2020 Nov 4;12(11):3250 doi: 10.3390/cancers12113250

“Open Sesame?”: impact of biomarker role and molecular mechanisms influencing the human equilibrative nucleoside transporter-1 in the uptake and cytotoxicity of gemcitabine in pancreatic cancer. Randazzo O, Papini F, Mantini G, Gregori A, Parrino B, Liu DSK, Cascioferro S, Carbone D, Peters GJ, Frampton AE, Garajova I, Giovannetti E. Cancers 2020 Oct 31;12(11):3206 doi: 10.3390/cancers12113206

The role of alternative splicing in cancer: from oncogenesis to drug resistance. Sciarrillo R, Wojtuszkiewicz A, Assaraf YG, Jansen G, Kaspers GJL, Giovannetti E, Cloos J. Drug Resist Updates 2020 Dec;53:100728 doi: 10.1016/j.drup.2020.100728

New Imidazo[2,1-b][1,3,4]Thiadiazole Derivatives Inhibit FAK Phosphorylation and Potentiate the Antiproliferative Effects of Gemcitabine Through Modulation of the Human Equilibrative Nucleoside Transporter-1 in Peritoneal Mesothelioma. Li Petri G, Pecoraro C, Randazzo O, Zoppi S, Cascioferro SM, Parrino B, Carbone D, El Hassouni B, Cavazzoni A, Zaffaroni N, Cirrincione G, Diana P, Peters GJ, Giovannetti E. Anticancer Res. 2020 Sep;40(9):4913-4919 doi: 10.21873/anticanres.14494

The Role of the Microbiome in Cancer and Therapy Efficacy: Focus on Lung Cancer. Halley A, Leonetti A, Gregori A, Tiseo M, Deng DM, Giovannetti E, Peters GJ. Anticancer Res. 2020 Sep;40(9):4807-4818 doi: 10.21873/anticanres.14484

Pancreatic cancer resistance conferred by stellate cells: looking for new preclinical models. Che PP, Gregori A, Firuzi O, Dahele M, Sminia P, Peters GJ, Giovannetti E. Exp Hematol Oncol. 2020 Aug 3;9:18 doi: 10.1186/s40164-020-00176-0

Comment on: Targeting the HGF/c-MET pathway in advanced pancreatic cancer: a key element of treatment that limits primary tumour growth and eliminates metastasis. Che PP, Gregori A, Peters GJ, Dahele M, Sminia P, Giovannetti E. Br J Cancer. 2020 Oct;123(9):1464-1465 doi: 10.1038/s41416-020-1003-7

Of fungi and men: role of fungi in pancreatic cancer carcinogenesis. Wang H, Capula M, Krom BP, Yee D, Giovannetti E,* Deng D.* (*equally contributed) Ann Transl Med 2020 Oct;8(19):1257 doi: 10.21037/atm-20-2723

NUC-1031 in biliary tract cancer: from bench to bedside and back? Boyd LNC, Peters GJ, Kazemier G, Giovannetti E. Cancer Chemother Pharmacol 2020 Jun;85(6):1011-1014 doi: 10.1007/s00280-020-04080-6

Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds. Br J Cancer. Li Petri G, El Hassouni B, Sciarrillo R, Funel N, Mantini G, Zeeuw van der Laan EA, Cascioferro S, Avan A, Zucali PA, Zaffaroni N, Lagerweij T, Parrino B, Smid K, Deraco M, Granchi C, Braczko A, Smolenski RT, Matherly LH, Jansen G, Assaraf YG, Diana P, Cloos J, Peters GJ, Minutolo F, Giovannetti E. 2020 Aug;123(4):644-656 doi: 10.1038/s41416-020-0912-9

The role of Eph receptors in cancer and how to target them: novel approaches in cancer treatment. Buckens OJ, El Hassouni B, Giovannetti E, Peters GJ. Expert Opin Investig Drugs. 2020 Jun;29(6):567-582 doi: 10.1080/13543784.2020.1762566

Is there a role for dacomitinib, a second-generation irreversible inhibitor of the epidermal-growth factor receptor tyrosine kinase, in advanced non-small cell lung cancer? Bergonzini C, Leonetti A, Tiseo M, Giovannetti E, Peters GJ. Expert Opin Pharmacother. 2020 Apr 15;1-11 doi: 10.1080/14656566.2020.1746269

Their Benzofused Systems, and Thiazolidinone Derivatives: Versatile and Promising Tools to Combat Antibiotic Resistance. Cascioferro S, Parrino B, Carbone D, Schillaci D, Giovannetti E, Cirrincione G, Diana P. Thiazoles, J Med Chem. 2020 Aug 13;63(15):7923-7956 doi: 10.1021/acs.jmedchem.9b01245

Glucocorticoid Resistant Pediatric Acute Lymphoblastic Leukemia Samples Display Altered Splicing Profile and Vulnerability to Spliceosome Modulation. Sciarrillo R, Wojtuszkiewicz A, Kooi IE, Leon LG, Sonneveld E, Kuiper RP, Jansen G, Giovannetti E, Kaspers GJL, Cloos J. Cancers (Basel) 2020 Mar 19;12(3):723 doi: 10.3390/cancers12030723

Pemetrexed Enhances Membrane PD-L1 Expression and Potentiates T Cell-Mediated Cytotoxicity by Anti-PD-L1 Antibody Therapy in Non-Small-Cell Lung Cancer. Cavazzoni A, Digiacomo G, Alfieri R, La Monica S, Fumarola C, Galetti M, Bonelli M, Cretella D, Barili V, Zecca A, Giovannetti E, Fiorentino M, Tiseo M, Petronini PG, Ardizzoni A. Cancers 2020 Mar 12;12(3):666 doi: 10.3390/cancers12030666

Rigosertib potently protects against colitis-associated intestinal fibrosis and inflammation by regulating PI3K/AKT and NF-Œ∫B signaling pathways. Rahmani F, Asgharzadeh F, Avan A, Barneh F, Parizadeh MR, Ferns GA, Ryzhikov M, Ahmadian MR, Giovannetti E, Jafari M, Khazaei M, Hassanian SM. Life Sciences 2020 May 15;249:117470 doi: 10.1016/j.lfs.2020.117470

Imidazo[2,1-b] [1,3,4]thiadiazoles with antiproliferative activity against primary and gemcitabine-resistant pancreatic cancer cells. Cascioferro S, Petri GL, Parrino B, Carbone D, Funel N, Bergonzini C, Mantini G, Dekker H, Geerke D, Peters GJ, Cirrincione G, Giovannetti E, Diana P. Eur J Med Chem. 2020 Mar 1;189:112088 doi: 10.1016/j.ejmech.2020.112088

Crizotinib sensitizes the erlotinib resistant HCC827GR5 cell line by influencing lysosomal function. Van Der Steen N, Keller K, Dekker H, Porcelli L, Honeywell RJ, Van Meerloo J, Musters RJP, Kathmann I, Frampton AE, Liu DSK, Ruijtenbeek R, Rolfo C, Pauwels P, Giovannetti E, Peters GJ. J Cell Physiol. 2020 Nov;235(11):8085-8097 doi: 10.1002/jcp.29463

3-(6-Phenylimidazo [2,1-b][1,3,4]thiadiazol-2-yl)-1H-Indole Derivatives as New Anticancer Agents in the Treatment of Pancreatic Ductal Adenocarcinoma. Cascioferro S, Li Petri G, Parrino B, El Hassouni B, Carbone D, Arizza V, Perricone U, Padova A, Funel N, Peters GJ, Cirrincione G, Giovannetti E, Diana P. Molecules. 2020 Jan 14;25(2):329 doi: 10.3390/molecules25020329

Combined expression of plasma thrombospondin-2 and CA19-9 for diagnosis of pancreatic cancer and distal cholangiocarcinoma – A proteome approach. Le Large TYS, Meijer LL, Paleckyte R, Boyd LNC, Kok B, Wurdinger T, Schelfhorst T, Piersma SR, Pham TV, van Grieken NCT, Zonderhuis BM, Daams F, van Laarhoven HWM, Bijlsma MF, Jimenez CR, Giovannetti E,* Kazemier G.* (*equally contributed). Oncologist 2020 Apr;25(4):e634-e643 doi: 10.1634/theoncologist.2019-0680

Diagnosing pancreatic ductal adenocarcinoma using plasma extracellular vesicle RNA profiles. Frampton AE, Giovannetti E. Gut. 2020 Mar;69(3):404-405 doi: 10.1136/gutjnl-2019-319896

The Dichotomous Role of the Glycolytic Metabolism Pathway in Cancer Metastasis: Interplay with the Complex Tumor Microenvironment and Novel Therapeutic Strategies. El Hassouni B, Granchi C, Valles-Martí A, I Supadmanaba GP, Bononi G, Tuccinardi T, Funel N, Peters GJ, Jimenez CR, Giovannetti E*, Minutolo F* (*equally contributed). Sem Cancer Biol 2020;60:238-248 doi: 10.1016/j.semcancer.2019.08.025

Plasma miR-181a-5p Down-Regulation Predicts Response and Improved Survival After FOLFIRINOX in Pancreatic Ductal Adenocarcinoma. Meijer LL, Garajova I, Caparello C, Le Large TY, Frampton A, Vasile E, Funel N, Kazemier G, Giovannetti E. Ann Surgery 2020;271(6):1137-1147 doi: 10.1097/SLA.0000000000003084

2019

Germline investigation in male breast cancer of DNA repair genes by next-generation sequencing. Scarpitta R, Zanna I, Aretini P, Gambino G, Scatena C, Mei B, Ghilli M, Rossetti E, Roncella M, Congregati C, Bonci F, Naccarato AG, Palli D, Caligo MA. Breast Cancer Res Treat. 2019 Dec;178(3): 557-564.

Brain-targeted enzyme-loaded nanoparticles: A breach through the blood-brain barrier for enzyme replacement therapy in Krabbe disease. Del Grosso A, Galliani M, Angella L, Santi M, Tonazzini I, Parlanti G, Signore G, Cecchini M. Science Advances, Volume 5, Issue 11, 20 November 2019.

HGF/MET pathway aberrations as diagnostic, prognostic, and predictive biomarkers in human cancers. Moosavi F, Giovannetti E, Saso L, Firuzi O. Crit Rev Clin Lab Sci. 2019 Dec;56(8):533-566.

Resistance mechanisms to osimertinib in EGFR-mutated non-small cell lung cancer. Leonetti A, Sharma S, Minari R, Perego P, Giovannetti E, Tiseo M. Br J Cancer. 2019 Oct;121(9):725-737.

Fast-diffusing p75NTR monomers support apoptosis and growth cone collapse by neurotrophin ligands. Marchetti L, Bonsignore F, Gobbo F, Amodeo R, Calvello M, Jacob A, Signore G, Schirripa Spagnolo C, Porciani D, Mainardi M, Beltram F, Luin S, Cattaneo A. Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21563-21572.

PTEN Alterations as a Potential Mechanism for Tumor Cell Escape from PD-1/PD-L1 Inhibition. Cretella D, Digiacomo G, Giovannetti E, Cavazzoni A. Cancers (Basel). 2019 Sep 6;11(9).

Mouse mammary tumor virus (MMTV) – like exogenous sequences are associated with sporadic but not hereditary human breast carcinoma. Naccarato AG, Lessi F, Zavaglia K, Scatena C, Al Hamad MA, Aretini P, Menicagli M, Roncella M, Ghilli M, Caligo MA, Mazzanti CM, Bevilacqua G. Aging (Albany NY). 2019 Sep 13;11(17):7236-7241.

Molecular basis and rationale for combining immune checkpoint inhibitors with chemotherapy in non-small cell lung cancer. Leonetti A, Wever B, Mazzaschi G, Assaraf YG, Rolfo C, Quaini F, Tiseo M, Giovannetti E. Drug Resist Updat. 2019 Sep;46:100644.

Dabrafenib and Trametinib prolong coagulation through the inhibition of tissue factor in BRAFv600e mutated melanoma cells in vitro. Scatena C, Franceschi S, Franzini M, Sanguinetti C, Romiti N, Caponi L, Mandalà M, Mazzanti CM, Naccarato AG. Cancer Cell Int. 2019 Aug 28;19:223. doi: 10.1186/s12935-019-0938-3.

Remarkable Effect of [Li(G4)]TFSI Solvate Ionic Liquid (SIL) on the Regio- and Stereoselective Ring Opening of α-Gluco Carbasugar 1,2-Epoxides. Di Pietro S, Bordoni V, Mezzetta A, Chiappe C, Signore G, Guazzelli L, Di Bussolo V. Molecules. 2019 Aug 14;24(16).

Unravelling the Diagnostic Dilemma: A MicroRNA Panel of Circulating MiR-16 and MiR-877 as A Diagnostic Classifier for Distal Bile Duct Tumors. Meijer LL, Puik JR, Le Large TYS, Heger M, Dijk F, Funel N, Wurdinger T, Garajová I, van Grieken NCT, van de Wiel MA, Giovannetti E, Kazemier G. Cancers (Basel). 2019 Aug 15;11(8). pii: E1181.

Can circulating tumor and exosomal nucleic acids act as biomarkers for pancreatic ductal adenocarcinoma? Liu DSK, Mato Prado M, Giovannetti E, Jiao LR, Krell J, Frampton AE. Expert Rev Mol Diagn. 2019 Jul;19(7):553-558.

Ultra-high resolution MALDI-FTICR-MSI analysis of intact proteins in mouse and human pancreas tissue. Piga I, Heijs B, Nicolardi S, Giusti L , Marselli L, Marchetti P, Mazzoni MR, Lucacchini, A., McDonnell, L.A. International Journal of Mass Spectrometry, Volume 437, March 2019, Pages 10-16.

Quantitative Microproteomics Based Characterization of the Central and Peripheral Nervous System of a Mouse Model of Krabbe Disease. Pellegrini D, Del Grosso A, Angella L, Giordano N, Dilillo M, Tonazzini I, Caleo M, Cecchini M, McDonnell LA. Mol Cell Proteomics. 2019 Jun;18(6):1227-1241.

Poly(Lactide‐Co‐Glycolide) Nanoparticles Co‐Loaded with Chlorophyllin and Quantum Dots as Photodynamic Therapy Agents. Galliani M, Signore G.  ChemPlusChem. Volume84, Issue11 November 2019, Pages 1653-1658.

Whole exome sequencing in familial isolated primary hyperparathyroidism. Cetani F, Pardi E, Aretini P, Saponaro F, Borsari S, Mazoni L, Apicella M, Civita P, La Ferla M, Caligo MA, Lessi F, Mazzanti CM, Torregrossa L, Oppo A, Marcocci C. J Endocrinol Invest. 2019 Sep 5.

The dichotomous role of the glycolytic metabolism pathway in cancer metastasis: Interplay with the complex tumor microenvironment and novel therapeutic strategies. El Hassouni B, Granchi C, Vallés-Martí A, Supadmanaba IGP, Bononi G, Tuccinardi T, Funel N, Jimenez CR, Peters GJ, Giovannetti E, Minutolo F. Semin Cancer Biol. 2019 Aug 21. pii: S1044-579X(19)30180-4.

ANKRD44 Gene Silencing: A Putative Role in Trastuzumab Resistance in Her2-Like Breast Cancer. La Ferla M, Lessi F, Aretini P, Pellegrini D, Franceschi S, Tantillo E, Menicagli M, Marchetti I, Scopelliti C, Civita P, De Angelis C, Diodati L, Bertolini I, Roncella M, McDonnell LA, Hochman J, Del Re M, Scatena C, Naccarato AG, Fontana A, Mazzanti CM. Front Oncol. 2019 Jun 26;9:547.

Biological Evaluation of the Antiproliferative and Anti-migratory Activity of a Series of 3-(6-Phenylimidazo[2,1-b][1,3,4]thiadiazol-2-yl)-1H-indole Derivatives Against Pancreatic Cancer Cells. Li Petri G, Cascioferro S, El Hassouni B, Carbone D, Parrino B, Cirrincione G, Peters GJ, Diana P, Giovannetti E. Anticancer Res. 2019 Jul;39(7):3615-3620.

Uridine Cytidine Kinase 2 as a Potential Biomarker for Treatment with RX-3117 in Pancreatic Cancer. El Hassouni B, Infante J, Mantini G, Ricci C, Funel N, Giovannetti E, Peters GJ.. Anticancer Res. 2019 Jul;39(7):3609-3614

A Brief Guide to Performing Pharmacological Studies In Vitro: Reflections from the EORTC-PAMM Course “Preclinical and Early-phase Clinical Pharmacology. Capula M, Corno C, El Hassouni B, Li Petri G, Aranđelović S; EORTC PAMM Group. Anticancer Res. 2019 Jul;39(7):3413-3418.

To Combine or Not Combine: Drug Interactions and Tools for Their Analysis. Reflections from the EORTC-PAMM Course on Preclinical and Early-phase. Clinical Pharmacology El Hassouni B, Mantini G, Li Petri G, Capula M, Boyd L, Weinstein HNW, Vallés-Marti A, Kouwenhoven MCM, Giovannetti E, Westerman BA, Peters GJ; EORTC PAMM Group. Anticancer Res. 2019 Jul;39(7):3303-3309.

Laser Capture Microdissection and RNA-Seq Analysis: High Sensitivity Approaches to Explain Histopathological Heterogeneity in Human Glioblastoma FFPE Archived Tissues. Civita P, Franceschi S, Aretini P, Ortenzi V, Menicagli M, Lessi F, Pasqualetti F, Naccarato AG, Mazzanti CM.. Front Oncol. 2019 Jun  7;9:482.

Rescuing cones and daylight vision in retinitis pigmentosa mice. Guadagni V, Biagioni M, Novelli E, Aretini P, Mazzanti CM, Strettoi E. FASEB J. 2019 Jun 14:fj201900414R.

Molecular profiling of microinvasive breast cancer microenvironment progression. Lessi F, Scatena C, Aretini P, Menicagli M, Franceschi S, Naccarato AG, Mazzanti CM. J Transl Med. 2019 Jun 3;17(1):187.

Pharmacogenetics of treatments for pancreatic cancer. El Hassouni B, Li Petri G, Liu DSK, Cascioferro S, Parrino B, Hassan W, Diana P, Ali A, Frampton AE, Giovannetti E.  Expert Opin Drug Metab Toxicol. 2019 Jun;15(6):437-447.

Decrease in phospho-PRAS40 plays a role in the synergy between erlotinib and crizotinib in an EGFR and cMET wild-type squamous non-small cell lung cancer cell line. Van Der Steen N, Leonetti A, Keller K, Dekker H, Funel N, Lardon F, Ruijtenbeek R, Tiseo M, Rolfo C, Pauwels P, Peters GJ, Giovannetti E. Biochem Pharmacol. 2019 Aug;166:128-138.

Role of c-MET Inhibitors in Overcoming Drug Resistance in Spheroid Models of Primary Human Pancreatic Cancer and Stellate Cells. Firuzi O, Che PP, El Hassouni B, Buijs M, Coppola S, Löhr M, Funel N, Heuchel R, Carnevale I, Schmidt T, Mantini G, Avan A, Saso L, Peters GJ, Giovannetti E. Cancers (Basel). 2019 May 8;11(5). pii: E638.

Nanocarriers for Protein Delivery to the Cytosol: Assessing the Endosomal Escape of Poly(Lactide-co-Glycolide)-Poly(Ethylene Imine) Nanoparticles. Galliani M, Tremolanti C, Signore G. Nanomaterials (Basel). 2019 Apr 23;9(4). pii: E652.

MICAL2 is expressed in cancer associated neo-angiogenic capillary endothelia and it is required for endothelial cell viability, motility and VEGF response. Barravecchia I, Mariotti S, Pucci A, Scebba F, De Cesari C, Bicciato S, Tagliafico E, Tenedini E, Vindigni C, Cecchini M, Berti G, Vitiello M, Poliseno L, Mazzanti CM, Angeloni D. Biochim Biophys Acta Mol Basis Dis. 2019 Apr 18. pii: S0925-4439(19)30119-X.

Monoallelic expression in melanoma. Silcock L, Almabrazi H, Mokrab Y, Jithesh P, Al-Hashmi M, James N, Mathew R, Mattei V, Bedognetti D, Lessi F, Temanni R, Seliger B, Al-Ali R, Marincola FM, Wang E, Tomei S. J Transl Med. 2019 Apr 5;17(1):112.

Overexpression of the cohesin-core subunit SMC1A contributes to colorectal cancer development. Sarogni P, Palumbo O, Servadio A, Astigiano S, D’Alessio B, Gatti V, Cukrov D, Baldari S, Pallotta MM, Aretini P, Dell’Orletta F, Soddu S, Carella M, Toietta G, Barbieri O, Fontanini G, Musio A. J Exp Clin Cancer Res. 2019 Mar 1;38(1):108.

2,6-Disubstituted imidazo[2,1-b][1,3,4]thiadiazole derivatives as potent staphylococcal biofilm inhibitors. Cascioferro S, Parrino B, Petri GL, Cusimano MG, Schillaci D, Di Sarno V, Musella S, Giovannetti E, Cirrincione G, Diana P. Eur J Med Chem. 2019 Apr 1;167:200-210.

Molecular characterization of low grade and high grade bladder cancer. Apollo A, Ortenzi V, Scatena C, Zavaglia K, Aretini P, Lessi F, Franceschi S, Tomei S, Sepich CA, Viacava P, Mazzanti CM, Naccarato AG.. PLoS One. 2019 Jan 16;14(1):e0210635.

Integrative Clustering in Mass Spectrometry Imaging for Enhanced Patient Stratification. Balluff B, Buck A, Martin-Lorenzo M, Dewez F, Langer R, McDonnell LA, Walch A, Heeren RMA. Proteomics Clin Appl. 2019 Jan;13(1):e1800137.

MicroRNAs as a drug resistance mechanism to targeted therapies in EGFR-mutated NSCLC: Current implications and future directions. Leonetti A, Assaraf YG, Veltsista PD, El Hassouni B, Tiseo M, Giovannetti E.  Drug Resist Updat. 2019 Jan;42:1-11.

Ultraviolet Photodissociation of ESI- and MALDI-Generated Protein Ions on a Q-Exactive Mass Spectrometer. Dilillo M, de Graaf EL, Yadav A, Belov ME, McDonnell LA.  J Proteome Res. 2019 Jan 4;18(1):557-564.

Development of a yeast-based system to identify new hBRAFV600E functional interactors. Lubrano S, Comelli L, Piccirilli C, Marranci A, Dapporto F, Tantillo E, Gemignani F, Gutkind JS, Salvetti A, Chiorino G, Cozza G, Chiariello M, Galli A, Poliseno L, Cervelli T. Oncogene. 2019 Feb;38(8):1355-1366.

The inherent molecular stigma in normal breast tissue of BRCA1/2 gene mutation carriers: TC1 and SYNGR2 genes involvement in neoplastic transformation. Mazzanti CM, Franceschi S, Scatena C, Menicagli M, Aretini P, Civita P, Scopelliti C, Tomei S, Tancredi M, Naccarato AG, Caligo MA, Lessi F. The inherent molecular stigma in normal breast tissue of BRCA1/2 gene mutation carriers: TC1 and SYNGR2 genes involvement in neoplastic transformation. January 17, 2019. Journal of Translational Sciences.

2018

Assessing the potential of sputtered gold nanolayers in mass spectrometry imaging for metabolomics applications. Ràfols, P., Vilalta, D., Torres, S., Calavia, R., Heijs, B., McDonnell, L.A., Brezmes, J., del Castillo, E., Yanes, O., Ramìrez, N., Correig, X. (2018) PLoS One. 2018 Dec 12;13(12):e0208908.

MicroRNAs distribution in different phenotypes of Aortic Stenosis. Fabiani, I., Pugliese, N.R., Calogero, E., Conte, L., Mazzanti, M.C., Scatena, C., Scopelliti, C., Tantillo, E., Passiatore, M., Angelillis, M., Naccarato, G.A., Di Stefano, R., Petronio, A.S., Di Bello, V. (2018) ci Rep. 2018 Jul 2;8(1):9953.

Mitochondrial enzyme GLUD2 plays a critical role in glioblastoma progression. Franceschi, S., Corsinovi, D., Lessi, F., Tantillo, E., Aretini, P., Menicagli, M., Scopelliti, C., Civita, P., Pasqualetti, F., Naccarato, A.G., Ori, M., Mazzanti, C.M. EBioMedicine. 2018 Nov;37:56-67.

Doxycycline, an inhibitor of mitochondrial biogenesis, effectively reduces cancer stem cells (CSCs) in early breast cancer patients: A clinical pilot study. Scatena, C., Roncella, M., Di Paolo, A., Aretini, P., Menicagli, M., Fanelli, G., Marini, C., Mazzanti, C.M., Ghilli, M., Sotgia, F., Lisanti, M.P., Naccarato, A.G. Front Oncol. 2018 Oct 12;8:452.

Mass spectrometry imaging: How will it affect clinical research in the future? Dilillo, M., Heijs, B., McDonnell, L.A. Expert Rev Proteomics. 2018 Sep;15(9):709-716.

Round robin study of formalin-fixed paraffin-embedded tissues in mass spectrometry imaging. Buck, A., Heijs, B., Beine, B., Schepers, J., Cassese, A., Heeren, R.M.A., McDonnell, L.A., Henkel, C., Walch, A., Balluff, B. Anal Bioanal Chem. 2018 Sep;410(23):5969-5980.

Serotonin depletion causes valproate-responsive manic-like condition and increased hippocampal neuroplasticity that are reversed by stress. Maddaloni, G., Migliarini, S., Napolitano, F., Giorgi, A., Nazzi, S., Biasci, D., De Felice, A., Gritti, M., Cavaccini, A., Galbusera, A., Franceschi, S., Lessi, F., Ferla, M.L., Aretini, P., Mazzanti, C.M., Tonini, R., Gozzi, A., Usiello, A., Pasqualetti, M. Sci Rep. 2018 Aug 7;8(1):11847.

Next generation sequencing technologies for a successful diagnosis in a cold case of Leigh syndrome. Aretini, P., Mazzanti, C.M., La Ferla, M., Franceschi, S., Lessi, F., De Gregorio, V., Nesti, C., Valetto, A., Bertini, V., Toschi, B., Battini, R., Caligo, M.A. BMC Neurol. 2018 Jul 20;18(1):99.

Mouse mammary tumour virus-like env nucleotide and p14 signal peptide are present in feline mammary carcinomas, but not in neoplastic or dysplastic canine mammary lesions. Civita, P., Menicagli, M., Scopelliti, C., Lessi, F., Millanta, F., Borsacchi, S., Parisi, F., Freer, G., Pistello, M., Mazzanti, C.M., Poli, A. (2018) PLoS One. 2018 Jul 24;13(7):e0200839.

Characterization of Degraded Proteins in Paintings Using Bottom-Up Proteomic Approaches: New Strategies for Protein Digestion and Analysis of Data. Orsini, S., Yadav, A., Dilillo, M., McDonnell, L.A., Bonaduce, I. Anal Chem. 2018 Jun 5;90(11):6403-6408.

Bacterial toxins and targeted brain therapy: New insights from cytotoxic necrotizing factor 1 (CNF1). Tantillo, E., Colistra, A., Vannini, E., Cerri, C., Pancrazi, L., Baroncelli, L., Costa, M., Caleo, M. Int J Mol Sci. 2018 May 31;19(6).

Association of mouse mammary tumor virus with human breast cancer: Histology, immunohistochemistry and polymerase chain reaction analyses. Lawson, J.S., Mazzanti, C., Civita, P., Menicagli, M., Ngan, C.C., Whitaker, N.J., Hochman, J., Braitbard, O., Yosufi, B., Glenn, W.K. Front Oncol. 2018 May 7;8:141.

Cancer astrocytes have a more conserved molecular status in long recurrence free survival (RFS) IDH1 wild-type glioblastoma patients: New emerging cancer players. Franceschi, S., Lessi, F., Aretini, P., Ortenzi, V., Scatena, C., Menicagli, M., La Ferla, M., Civita, P., Zavaglia, K., Scopelliti, C., Apollo, A., Carbone, F.G., Vannozzi, R., Bevilacqua, G., Pasqualetti, F., Naccarato, A.G., Mazzanti, C.M. Oncotarget. 2018 May 8;9(35):24014-24027.

Levels of miR-126 and miR-218 are elevated in ductal carcinoma in situ (DCIS) and inhibit malignant potential of DCIS derived cells. Volinia, S., Bertagnolo, V., Grassilli, S., Brugnoli, F., Manfrini, M., Galasso, M., Scatena, C., Mazzanti, C.M., Lessi, F., Naccarato, G., Caligo, A., Bianchini, E., Piubello, Q., Orvieto, E., Rugge, M., Natali, C., Reale, D., Vecchione, A., Warner, S., Croce, C.M., Capitani, S. Oncotarget. 2018 May 4;9(34):23543-23553.

Role of circulating endothelial progenitor cells in the reparative mechanisms of stable ischemic myocardium. Morrone, D., Felice, F., Scatena, C., De Martino, A., Picoi, M.L.E., Mancini, N., Blasi, S., Menicagli, M., Di Stefano, R., Bortolotti, U., Naccarato, A.G., Balbarini, A. Int J Cardiol. 2018 Apr 15;257:243-246.

Association of Glutathione S-Transferase P-1 (GSTP-1) rs1695 polymorphism with overall survival in glioblastoma patients treated with combined radio-chemotherapy. Pasqualetti, F., Gonnelli, A., Cantarella, M., Delishaj, D., Molinari, A., Ortenzi, V., Carbone, F., Montrone, S., Ursino, S., Franceschi, S., Morganti, R., Orlandi, P., Di Desidero, T., Mazzanti, C.M., Zavaglia, K., Naccarato, A.G., Bocci, G., Paiar, F. Invest New Drugs. 2018 Apr;36(2):340-345.

Interactive Visual Exploration of 3D Mass Spectrometry Imaging Data Using Hierarchical Stochastic Neighbor Embedding Reveals Spatiomolecular Structures at Full Data Resolution. Abdelmoula, W.M., Pezzotti, N., Holt, T., Dijkstra, J., Vilanova, A., McDonnell, L.A., Lelieveldt, B.P.F. J Proteome Res. 2018 Mar 2;17(3):1054-1064.

Mass spectrometry imaging of metabolites. Balluff, B., McDonnell, L.A. Methods Mol Biol. 2018;1730:345-357.

2017

Role of Glutathione S-Transferase P polymorphism rs51695 in glioblastoma patients treated with combined radio-chemotherapy F Pasqualetti, A Gonnelli, M Cantarella, D Durim, A Molinari, V Ortenzi, F Carbone, S Montrone, S Ursino, S Franceschi, R Morganti, P Orlandi, T Di Desiderio, CM Mazzanti, G Bocci, K Zavaglia, AG Naccarato, F Paiar, MD: Invest New Drugs. 2017 Sep 30.

SGLT2/ SGLT1 expression in renal tissue of patients with type 2 diabetes. A Solini, C Rossi, CM Mazzanti, A Proietti, H Koepsell, E Ferrannini. Diabetes Obes Metab. 2017 Sep;19(9):1289-1294

Role of circulating endothelial progenitor cells in the reparative mechanisms of stable ischemic myocardium. Morrone D, Felice F, Scatena C, De Martino A, Picoi MLE, Mancini N, Blasi S, Menicagli M, Di Stefano R, Bortolotti U, Naccarato AG, Balbarini A. Int J Cardiol. 2017 Sep 14. pii: S0167-5273(16)32271-9.

Whole-exome analysis of a Li-Fraumeni family trio with a novel TP53 PRD mutation and anticipation profile.Franceschi S, Spugnesi L, Aretini P, Lessi F, Scarpitta R, Galli A, Congregati C, Caligo MA, Mazzanti CM. Carcinogenesis. 2017 Sep 1;38(9):938-943.

Sodium-glucose co transporter (SGLT)2 and SGLT1 renal expression in patients with type 2 diabetes. Solini A, Rossi C, Mazzanti CM, Proietti A, Koepsell H, Ferrannini E. Diabetes Obes Metab. 2017 Sep;19(9):1289-1294.

CXCL12α/SDF-1 from perisynaptic Schwann cells promotes regeneration of injured motor axon terminals. Negro S, Lessi F, Duregotti E, Aretini P, La Ferla M, Franceschi S, Menicagli M, Bergamin E, Radice E, Thelen M, Megighian A, Pirazzini M, Mazzanti CM, Rigoni M, Montecucco C. EMBO Mol Med. 2017 Aug;9(8):1000-1010.

Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells. Lai M, Realini N, La Ferla M, Passalacqua I, Matteoli G, Ganesan A, Pistello M, Mazzanti CM, Piomelli D. Sci Rep. 2017 Aug 7;7(1):7411.

Mass Spectrometry Imaging, Laser Capture Microdissection, and LC-MS/MS of the Same Tissue Section. Dilillo M, Pellegrini D, Ait-Belkacem R, de Graaf EL, Caleo M, McDonnell LA. J Proteome Res. 2017 Aug 4;16(8):2993-3001.

Design and Performance of a Novel Interface for Combined Matrix-Assisted Laser Desorption Ionization at Elevated Pressure and Electrospray Ionization with Orbitrap Mass Spectrometry. Belov ME, Ellis SR, Dilillo M, Paine MRL, Danielson WF, Anderson GA, de Graaf EL, Eijkel GB, Heeren RMA, McDonnell LA. Anal Chem. 2017 Jul 18;89(14):7493-7501.

Polymorphisms and mutations in GSTP1, RAD51, XRCC1 and XRCC3 genes in breast cancer patients. Al Zoubi MS, Zavaglia K, Mazanti C, Al Hamad M, Al Batayneh K, Aljabali AAA, Bevilacqua G.Int J Biol Markers. 2017 Jul 24;32(3):e337-e343.

Whole-exome analysis in osteosarcoma to identify a personalized therapy. Chiappetta C, Mancini M, Lessi F, Aretini P, De Gregorio V, Puggioni C, Carletti R, Petrozza V, Civita P, Franceschi S, Naccarato AG, Rocca CD, Mazzanti CM, Di Cristofano C. Oncotarget. 2017 Jul 5;8(46):80416-80428.

Design and Performance of a Novel Interface for Combined Matrix-Assisted Laser Desorption Ionization at Elevated Pressure and Electrospray Ionization with Orbitrap Mass Spectrometry. Belov ME, Ellis SR, Dilillo M, Paine MRL, Danielson WF, Anderson GA, de Graaf EL, Eijkel GB, Heeren RMA, McDonnell LA. Anal Chem. 2017 Jul 18;89(14):7493-7501.

Mass spectrometry imaging shows major derangements in neurogranin and in purine metabolism in the triple-knockout 3×Tg Alzheimer mouse model. Esteve C, Jones EA, Kell DB, Boutin H, McDonnell LA. Biochim Biophys Acta. 2017 Jul;1865(7):747-754.

Loss of c-KIT expression in thyroid cancer cells. S Franceschi, F Lessi, F Panebianco, E Tantillo, M La Ferla, M Menicagli, P Aretini, A Apollo, AG Naccarato, I Marchetti, CM Mazzanti. PLoS One. 2017 Mar 16;12(3)

Preface. Drake RR, McDonnell LA. Adv Cancer Res. 2017;134:xiii-xiv.

Mass Spectrometry Imaging in Cancer Research: Future Perspectives. McDonnell LA, Angel PM, Lou S, Drake RR. Adv Cancer Res. 2017;134:283-290.

Ultra-High Mass Resolution MALDI Imaging Mass Spectrometry of Proteins and Metabolites in a Mouse Model of Glioblastoma. Dilillo M, Ait-Belkacem R, Esteve C, Pellegrini D, Nicolardi S, Costa M, Vannini E, Graaf EL, Caleo M, McDonnell LA. Sci Rep. 2017 Apr 4;7(1):603.

Mouse mammary tumor-like virus (MMTV) is present in human breast tissue before development of virally associated breast cancer. Nartey T, Mazzanti CM, Melana S, Glenn WK, Bevilacqua G, Holland JF, Whitaker NJ, Lawson JS, Pogo BGT. Infect Agent Cancer. 2017 Mar 15;12:16.

Human Plasma N-glycosylation as Analyzed by Matrix-Assisted Laser Desorption/Ionization-Fourier Transform Ion Cyclotron Resonance-MS Associates with Markers of Inflammation and Metabolic Health. Reiding KR, Ruhaak LR, Uh HW, El Bouhaddani S, van den Akker EB, Plomp R, McDonnell LA, Houwing-Duistermaat JJ, Slagboom PE, Beekman M, Wuhrer M. Mol Cell Proteomics. 2017 Feb;16(2):228-242.

Prognostic Metabolite Biomarkers for Soft Tissue Sarcomas Discovered by Mass Spectrometry Imaging. Lou S, Balluff B, Cleven AH, Bovée JV, McDonnell LA. J Am Soc Mass Spectrom. 2017 Feb;28(2):376-383.

Hybrid Imaging Labels: Providing the Link Between Mass Spectrometry-Based Molecular Pathology and Theranostics. Buckle T, van der Wal S, van Malderen SJ, Müller L, Kuil J, van Unen V, Peters RJ, van Bemmel ME, McDonnell LA, Velders AH, Koning F, Vanhaeke F, van Leeuwen FW. Theranostics. 2017 Jan 12;7(3):624-633.

2016

de Graaf EL, Pellegrini D, McDonnell LA. Set of Novel Automated Quantitative Microproteomics Protocols for Small Sample Amounts and Its Application to Kidney Tissue Substructures. J Proteome Res. 2016 Dec 2;15(12):4722-4730.

Ait-Belkacem R, Dilillo M, Pellegrini D, Yadav A, de Graaf EL, McDonnell LA. In-Source Decay and Pseudo-MS(3) of Peptide and Protein Ions Using Liquid AP-MALDI. J Am Soc Mass Spectrom. 2016 Dec;27(12):2075-2079.

Fabiani I, Scatena C, Mazzanti CM, Conte L, Pugliese NR, Franceschi S, Lessi F, Menicagli M, De Martino A, Pratali S, Bortolotti U, Naccarato AG, La Carrubba S, Di Bello V. Micro-RNA-21 (biomarker) and global longitudinal strain (functional marker) in detection of myocardial fibrotic burden in severe aortic valve stenosis: a pilot study. J Transl Med. 2016 Aug 27;14(1):248.

Ly A, Buck A, Balluff B, Sun N, Gorzolka K, Feuchtinger A, Janssen KP, Kuppen PJ, van de Velde CJ, Weirich G, Erlmeier F, Langer R, Aubele M, Zitzelsberger H, McDonnell L, Aichler M, Walch A. High-mass-resolution MALDI mass spectrometry imaging of metabolites from formalin-fixed paraffin-embedded tissue. Nat Protoc. 2016 Aug;11(8):1428-43.

Heijs B, Holst S, Briaire-de Bruijn IH, van Pelt GW, de Ru AH, van Veelen PA, Drake RR, Mehta AS, Mesker WE, Tollenaar RA, Bovée JV, Wuhrer M, McDonnell LA. Multimodal Mass Spectrometry Imaging of N-Glycans and Proteins from the Same Tissue Section. Anal Chem. 2016 Aug 2;88(15):7745-53.

Spugnesi L, Gabriele M, Scarpitta R, Tancredi M, Maresca L, Gambino G, Collavoli A, Aretini P, Bertolini I, Salvadori B, Landucci E, Fontana A, Rossetti E, Roncella M, Naccarato GA, Caligo MA. Germline mutations in DNA repair genes may predict neoadjuvant therapy response in triple negative breast patients. Genes Chromosomes Cancer. 2016 Dec;55(12):915-924.

Schmidlin T, Garrigues L, Lane CS, Mulder TC, van Doorn S, Post H, de Graaf EL, Lemeer S, Heck AJ, Altelaar AF. Assessment of SRM, MRM(3) , and DIA for the targeted analysis of phosphorylation dynamics in non-small cell lung cancer. Proteomics. 2016 Aug;16(15-16):2193-205.

Cassese A, Ellis SR, Ogrinc Potočnik N, Burgermeister E, Ebert M, Walch A, van den Maagdenberg AM, McDonnell LA, Heeren RM, Balluff B. Spatial Autocorrelation in Mass Spectrometry Imaging. Anal Chem. 2016 Jun 7;88(11):5871-8.

Lou S, Balluff B, de Graaff MA, Cleven AH, Briaire-de Bruijn I, Bovée JV, McDonnell LA. High-grade sarcoma diagnosis and prognosis: Biomarker discovery by mass spectrometry imaging. Proteomics. 2016 Jun;16(11-12):1802-13.

Holst S, Heijs B, de Haan N, van Zeijl RJ, Briaire-de Bruijn IH, van Pelt GW, Mehta AS, Angel PM, Mesker WE, Tollenaar RA, Drake RR, Bovée JV, McDonnell LA, Wuhrer M. Linkage-Specific in Situ Sialic Acid Derivatization for N-Glycan Mass Spectrometry Imaging of Formalin-Fixed Paraffin-Embedded Tissues. Anal Chem. 2016 Jun 7;88(11):5904-13.

Mulder IA, Esteve C, Wermer MJ, Hoehn M, Tolner EA, van den Maagdenberg AM, McDonnell LA. Funnel-freezing versus heat-stabilization for the visualization of metabolites by mass spectrometry imaging in a mouse stroke model. Proteomics. 2016 Jun;16(11-12):1652-9.

Franceschi S, Lessi F, Aretini P, Mazzanti CM, Menicagli M, La Ferla M, De Gregorio V, Caramella D, Naccarato AG, Bevilacqua G, Bonadio AG, Pasqualetti F. Molecular portrait of a rare case of metastatic glioblastoma: somatic and germline mutations using whole-exome sequencing. Neuro Oncol. 2016 Feb;18(2):298-300.

Lai M, Pifferi M, Bush A, Piras M, Michelucci A, Di Cicco M, del Grosso A, Quaranta P, Cursi C, Tantillo E, Franceschi S, Mazzanti MC, Simi P, Saggese G, Boner A, Pistello M. Gene editing of DNAH11 restores normal cilia motility in primary ciliary dyskinesia. J Med Genet. 2016 Apr;53(4):242-9.

Mariotti S, Barravecchia I, Vindigni C, Pucci A, Balsamo M, Libro R, Senchenko V, Dmitriev A, Jacchetti E, Cecchini M, Roviello F, Lai M, Broccoli V, Andreazzoli M, Mazzanti CM, Angeloni D. MICAL2 is a novel human cancer gene controlling mesenchymal to epithelial transition involved in cancer growth and invasion. Oncotarget. 2016 Jan 12;7(2):1808-25.

Franceschi S, Tomei S, Mazzanti CM, Lessi F, Aretini P, La Ferla M, De Gregorio V, Pasqualetti F, Zavaglia K, Bevilacqua G, Naccarato AG. Association between RAD 51 rs1801320 and susceptibility to glioblastoma. J Neurooncol. 2016 Jan;126(2):265-70.