02.06.20 – Molecular Imaging approaches and imaging Biomarkers in Translational Animal Models
Molecular imaging (MI) aims to characterize and quantify biological/biochemical patterns in living subjects, and is based on the use of specific molecular probes as well or exploits the intrinsic properties of a target biological tissue. By the integration of different MI techniques key information about the tissue remodeling and selected biochemical pathways can be provided in vivo, non-invasively, thus leading to the characterization of the lesions and the evaluation of a specific treatment. MI is based on the acquisition of images spanning from different spatial and temporal resolutions, with the capacity of performing longitudinal studies in the same animal model. Nowadays, MI is applied in drug development process with the aims to perform an early selection of new lead candidates, shortening the overall drug development process to move to clinical trials, by providing a better selection of candidate therapies, assessment of dose response, and the evaluation of biodistribution, pharmacodynamics and pharmacokinetics. Ongoing studies and applications at the CNR IFC and FTGM ecosystem will be presented.
Topic of the seminar:
• Molecular imaging for quantify biological processes
• Design preclinical experiments for MI
• Development of imaging biomarkers
• Methodological aspect and application @ CNR IFC and FGTM