Alessandra Giorgetti (ORCID: 0000-0001-5803-3567) and her group are studying the molecular mechanisms that regulate human hematopoietic stem cell development, differentiation and oncogenic transformation.
She holds a PhD in Molecular Medicine (2004) from the University of Milan, (Italy). She continued her Postdoc in Dr. Rafii’s Laboratory, at Weill Cornell Medical College in New York. She then was a Research Associate (2008-2011) at the Center of Regenerative Medicine of Barcelona (CMRB). There, she consolidated her skills in stem cells and acquired invaluable knowledge in reprogramming technologies. In 2012 she was appointed as head of the Laboratory of Hematopoiesis and Blood Disorders at the Inbiomed Foundation, San Sebastian (Spain). In 2014 she was awarded with the prestigious Spanish grant Ramon y Cajal, in the area of Biomedicine. After two years in Pablo Menendez’ Lab, at the Josep Carreras Leukaemia Research Institute, Alessandra joined CMRB as Group Leader.
Currently, her main research line is focused on the GATA2 transcription factor and its role in normal and malignant hematopoiesis. Employing multi-OMICs methodologies (genome, transcriptome and epigenome), human induced pluripotent stem cells (hiPSCs) and in vivo experimental models she is interested in understanding how GATA2 regulates normal hematopiesis and how heterozigous germline GATA2 mutations contribute to myeloid dysplastic syndrome and acute myeloid leukemia development.