Laboratory of Proteomics and Metabolomics
Current high throughput technologies, such as Next-Generation Sequencing (NGS) and Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS), generate huge amount of data, which need to be mined to answer any biologically relevant question. Bioinformatics is an interdisciplinary area of science that develops methods and software for the analysis and interpretation of the biological information.
Whole exome sequencing experiments report thousands of small genomic variants (SNPs, MNPs, insertion, deletion), whose possible expression at proteome level needs to be verified. To this aim, it is necessary to perform mass spectrometry analysis on the same cohort of samples that was subjected to exome sequencing and to incorporate the genomic data into existing proteomics data analysis pipeline.
Avinash Yadav has developed a software tool, VarProt, able to generate variant proteins that could be present in the sample as a result of genomic variants.
Avinash Yadav received his Master’s degree in Bioinformatics and Natural Sciences at the University of Turku, Finland. As part of thesis he designed and developed a novel software tool, PepRecon for visualization and analysis of LC/ESI-MS/MS data. This web-based tool can be utilized in guided gas-phase fractionation, able to reduce the sample complexity when analyzing proteins by shotgun proteomics.