Laboratory of Genomics and Transcriptomics
Breast cancer is a heterogeneous disease with varied morphological appearances, molecular features, behaviour, and response to therapy. According with Nottingham Grading System, one of the best-established prognostic factors in breast cancer is histological grade that shown to be able to generate important information related to the clinical behaviour of breast cancers. The grade of progress indicates a worsening of the prognosis, usually metastases are present in the later stages of the disease.
Claudia Scopelliti’s project aims to discover genomic differences between samples of Breast Cancer with and without metastasis. Her study is performed with NGS technology (exome and trascriptome sequencing) to analyze the mechanism responsible for the dissemination of tumor cells into axillary lymph nodes in order to better understand lymph nodes metastases phenomenon.
Claudia Scopelliti received her Master’s degree in Cellular and Molecular Biology at the University of Pisa.
She is a Student of the PhD program in Clinical and Translational Science of the University of Pisa and spends most of her research time at the FPS Institute in the Genomic Section, under the supervision of Francesca Lessi.