Laboratory of Proteomics and Metabolomics
Davide Pellegrini is focused on optimizing sample preparation protocols for the analysis of volume-limited samples by nanoLC-MS/MS. Through a close collaboration with the National Enterprise for nanoScience and Technology (NEST), he will develop and optimize a microfluidic device for the ultrasensitive processing of volume-limited samples for LC-MS/MS, both body fluids and cell/tissue based. The ability of microfluidic devices to manipulate small sample amounts, avoiding sample transfers and minimizing sample losses, will be explored to achieve the extreme sensitivity required for the analysis of individual microdissected tissue samples and cerebrospinal fluids from individual mice (in rodent models of gliobastoma and neuronological disorders).
Before his admission to the PhD program, at the Institute of Chemistry of Organometallic Compounds of CNR in Pisa, Davide Pellegrini studied the interaction between proteins and natural dyes with spectroscopic techniques and worked on the development of chromatographic techniques for the analysis of clinical biological samples. This provided a solid understanding of the LC-MS/MS technique needed for his PhD.
He received his Master degree in Chemistry at the University of Pisa
He is a Student of the PhD program in Biophysical Science of the Scuola Normale Superiore and spends most of his research time at the FPS Institute for Biomedical Research, under the supervision of Liam McDonnell.